Detalhe da pesquisa
1.
Quantifying the activity profile of ASO and siRNA conjugates in glioblastoma xenograft tumors in vivo.
Nucleic Acids Res
; 2024 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38613388
2.
A combinatorial approach for achieving CNS-selective RNAi.
Nucleic Acids Res
; 2024 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38348876
3.
Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection.
Proc Natl Acad Sci U S A
; 120(11): e2219523120, 2023 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36893269
4.
G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects.
Nucleic Acids Res
; 50(22): 12657-12673, 2022 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36511872
5.
Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts.
Nucleic Acids Res
; 50(15): 8418-8430, 2022 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35920332
6.
Silencing Apoe with divalent-siRNAs improves amyloid burden and activates immune response pathways in Alzheimer's disease.
Alzheimers Dement
; 20(4): 2632-2652, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38375983
7.
RNAi-based modulation of IFN-γ signaling in skin.
Mol Ther
; 30(8): 2709-2721, 2022 08 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35477658
8.
An RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis.
Mol Ther
; 30(3): 1329-1342, 2022 03 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34774753
9.
The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy.
Nucleic Acids Res
; 48(14): 7665-7680, 2020 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32672813
10.
Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin.
Nat Commun
; 14(1): 7099, 2023 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-37925520
11.
Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1.
Mol Ther Nucleic Acids
; 29: 135-149, 2022 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35847173
12.
Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy.
Mol Ther Nucleic Acids
; 21: 991-1005, 2020 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32818923
13.
2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA.
Mol Ther Nucleic Acids
; 21: 266-277, 2020 Sep 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32610253