Detalhe da pesquisa
1.
Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells.
J Neuroinflammation
; 15(1): 54, 2018 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29467002
2.
Safety and Tolerability of KIO-101 Eye Drops in Healthy Volunteers and Patients with Ocular Surface Disease-A Phase I Study.
Pharmaceutics
; 16(3)2024 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38543260
3.
A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis - A phase I clinical trial.
Front Med (Lausanne)
; 9: 1023224, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36325389
4.
Effective inhibition of experimental metastasis and prolongation of survival in mice by a potent factor Xa-specific synthetic serine protease inhibitor with weak anticoagulant activity.
Thromb Haemost
; 94(5): 1084-93, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16363253
5.
Urokinase-type plasminogen activator (uPA) and its receptor (uPAR): development of antagonists of uPA/uPAR interaction and their effects in vitro and in vivo.
Curr Pharm Des
; 9(19): 1529-43, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12871066
6.
Inhibition of the tumor-associated urokinase-type plasminogen activation system: effects of high-level synthesis of soluble urokinase receptor in ovarian and breast cancer cells in vitro and in vivo.
Recent Results Cancer Res
; 162: 43-63, 2003.
Artigo
em Inglês
| MEDLINE | ID: mdl-12790320
7.
Interaction of plasminogen activator inhibitor type-1 (PAI-1) with vitronectin (Vn): mapping the binding sites on PAI-1 and Vn.
Biol Chem
; 383(7-8): 1143-9, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12437099
8.
(R)-3-Amidinophenylalanine-derived inhibitors of factor Xa with a novel active-site binding mode.
Biol Chem
; 383(7-8): 1185-91, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12437104
9.
Interaction of plasminogen activator inhibitor type-1 (PAI-1) with vitronectin.
Eur J Biochem
; 269(1): 184-92, 2002 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-11784312