Detalhe da pesquisa
1.
Pharmacodynamics of selective inhibition of γ-secretase by avagacestat.
J Pharmacol Exp Ther
; 344(3): 686-95, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23275065
2.
Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain.
Bioorg Med Chem Lett
; 23(22): 6188-91, 2013 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24070783
3.
Atropisomeric 3-(beta-hydroxyethyl)-4-arylquinolin-2-ones as Maxi-K potassium channel openers.
J Med Chem
; 50(5): 1050-7, 2007 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-17274609
4.
3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR.
J Med Chem
; 50(3): 528-42, 2007 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-17266205
5.
4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: novel maxi-K channel opening relaxants of corporal smooth muscle targeted for erectile dysfunction.
J Med Chem
; 46(14): 2819-22, 2003 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-12825925
6.
4,5-diphenyltriazol-3-ones: openers of large-conductance Ca(2+)-activated potassium (maxi-K) channels.
J Med Chem
; 45(14): 2942-52, 2002 Jul 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-12086481
7.
Synthesis and structure-activity relationship of acrylamides as KCNQ2 potassium channel openers.
J Med Chem
; 47(11): 2887-96, 2004 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15139767
8.
(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]- 3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine.
J Med Chem
; 46(15): 3197-200, 2003 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-12852750
9.
Radiochemical synthesis and biodistribution of a novel maxi-K potassium channel opener.
Nucl Med Biol
; 29(1): 55-9, 2002 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-11786276
10.
Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor.
ACS Med Chem Lett
; 1(3): 120-4, 2010 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900185
11.
Analogs of a potent maxi-K potassium channel opener with an improved inhibitory profile toward cytochrome P450 isozymes.
Bioorg Med Chem Lett
; 15(19): 4286-90, 2005 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16061379
12.
(S,E)-N-[1-(3-heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity.
Bioorg Med Chem Lett
; 15(2): 363-6, 2005 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-15603955
13.
The synthesis and structure-activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection.
Bioorg Med Chem Lett
; 12(13): 1779-83, 2002 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-12067560
14.
Novel openers of Ca2+-dependent large-conductance potassium channels: symmetrical pharmacophore and electrophysiological evaluation of bisphenols.
Bioorg Med Chem Lett
; 13(8): 1437-9, 2003 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-12668007
15.
The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: a new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for urge urinary incontinence.
Bioorg Med Chem Lett
; 12(7): 1117-20, 2002 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-11909730
16.
Inhibition of disease progression by a novel retinoid antagonist in animal models of arthritis.
J Rheumatol
; 30(2): 355-63, 2003 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-12563696
17.
3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction.
Bioorg Med Chem Lett
; 14(20): 5089-93, 2004 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-15380205
18.
An assessment of the effects of serotonin 6 (5-HT6) receptor antagonists in rodent models of learning.
J Pharmacol Exp Ther
; 307(2): 682-91, 2003 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-12975483
19.
The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels.
Bioorg Med Chem Lett
; 12(7): 1023-6, 2002 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-11909708
20.
Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides.
Bioorg Med Chem Lett
; 14(17): 4533-7, 2004 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15357987