Detalhe da pesquisa
1.
ACE2 acts as a novel regulator of TMPRSS2-catalyzed proteolytic activation of influenza A virus in airway cells.
J Virol
; 98(4): e0010224, 2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38470058
2.
Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B-NS3 protease.
Arch Pharm (Weinheim)
; : e2400250, 2024 May 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38809037
3.
Thermodynamic characterization of a macrocyclic Zika virus NS2B/NS3 protease inhibitor and its acyclic analogs.
Arch Pharm (Weinheim)
; 356(4): e2200518, 2023 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-36480352
4.
Design, synthesis, and characterization of novel fluorogenic substrates of the proprotein convertases furin, PC1/3, PC2, PC5/6, and PC7.
Anal Biochem
; 655: 114836, 2022 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35964735
5.
Transcriptome profiling and protease inhibition experiments identify proteases that activate H3N2 influenza A and influenza B viruses in murine airways.
J Biol Chem
; 295(33): 11388-11407, 2020 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32303635
6.
RNase P Inhibitors Identified as Aggregators.
Antimicrob Agents Chemother
; 65(8): e0030021, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-33972249
7.
The Amino Acid at Position 8 of the Proteolytic Cleavage Site of the Mumps Virus Fusion Protein Affects Viral Proteolysis and Fusogenicity.
J Virol
; 94(22)2020 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32907974
8.
Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effect.
J Enzyme Inhib Med Chem
; 36(1): 659-668, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33641565
9.
NMR-Based Structural Characterization of a Two-Disulfide-Bonded Analogue of the FXIIIa Inhibitor Tridegin: New Insights into Structure-Activity Relationships.
Int J Mol Sci
; 22(2)2021 Jan 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33477282
10.
Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism.
Proc Natl Acad Sci U S A
; 113(40): 11196-11201, 2016 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27647913
11.
X-ray Structures of the Proprotein Convertase Furin Bound with Substrate Analogue Inhibitors Reveal Substrate Specificity Determinants beyond the S4 Pocket.
Biochemistry
; 57(6): 925-934, 2018 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29314830
12.
A Fluorescent-Labeled Phosphono Bisbenzguanidine As an Activity-Based Probe for Matriptase.
Chemistry
; 23(22): 5205-5209, 2017 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28370501
13.
Surface glycoprotein of Borna disease virus mediates virus spread from cell to cell.
Cell Microbiol
; 18(3): 340-54, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26332529
14.
Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication.
J Enzyme Inhib Med Chem
; 32(1): 712-721, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-28385094
15.
Protein-Templated Formation of an Inhibitor of the Blood Coagulation Factorâ Xa through a Background-Free Amidation Reaction.
Angew Chem Int Ed Engl
; 56(13): 3718-3722, 2017 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28199769
16.
Limiting the Number of Potential Binding Modes by Introducing Symmetry into Ligands: Structure-Based Design of Inhibitors for Trypsin-Like Serine Proteases.
Chemistry
; 22(2): 610-25, 2016 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26625703
17.
Interaction exists between matriptase inhibitors and intestinal epithelial cells.
J Enzyme Inhib Med Chem
; 31(5): 736-41, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26118419
18.
In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells.
J Enzyme Inhib Med Chem
; 31(sup2): 123-129, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27277342
19.
Changing the selectivity profile - from substrate analog inhibitors of thrombin and factor Xa to potent matriptase inhibitors.
J Enzyme Inhib Med Chem
; 31(sup1): 89-97, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27168215
20.
Impact of protein and ligand impurities on ITC-derived protein-ligand thermodynamics.
Biochim Biophys Acta
; 1840(9): 2843-50, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24792574