Detalhe da pesquisa
1.
Botulinum and Tetanus Neurotoxins.
Annu Rev Biochem
; 88: 811-837, 2019 06 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30388027
2.
Structural and functional insights into the Pseudomonas aeruginosa glycosyltransferase WaaG and the implications for lipopolysaccharide biosynthesis.
J Biol Chem
; 299(10): 105256, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37716703
3.
Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir.
J Biol Chem
; 298(8): 102169, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35732208
4.
Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy.
PLoS Biol
; 18(3): e3000618, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32182233
5.
Massively parallel variant characterization identifies NUDT15 alleles associated with thiopurine toxicity.
Proc Natl Acad Sci U S A
; 117(10): 5394-5401, 2020 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32094176
6.
Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus.
Biochemistry
; 61(2): 92-106, 2022 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34941255
7.
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
J Biol Chem
; 296: 100568, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753169
8.
Reaction Mechanism of Human PAICS Elucidated by Quantum Chemical Calculations.
J Am Chem Soc
; 144(31): 14258-14268, 2022 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35914774
9.
Development of a chemical probe against NUDT15.
Nat Chem Biol
; 16(10): 1120-1128, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32690945
10.
Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.
Nucleic Acids Res
; 48(21): 12234-12251, 2020 12 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33211885
11.
Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.
J Biol Chem
; 295(33): 11656-11668, 2020 08 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32571877
12.
MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.
J Biol Chem
; 295(15): 4761-4772, 2020 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32144205
13.
A ribonucleotide reductase from Clostridium botulinum reveals distinct evolutionary pathways to regulation via the overall activity site.
J Biol Chem
; 295(46): 15576-15587, 2020 11 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32883811
14.
The Structure and Classification of Botulinum Toxins.
Handb Exp Pharmacol
; 263: 11-33, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-31792680
15.
Mechanism of Ganglioside Receptor Recognition by Botulinum Neurotoxin Serotype E.
Int J Mol Sci
; 22(15)2021 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34361086
16.
Synaptotagmin Binding to Botulinum Neurotoxins.
Biochemistry
; 59(4): 491-498, 2020 02 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31809018
17.
Structural basis for the interaction of the chaperone Cbp3 with newly synthesized cytochrome b during mitochondrial respiratory chain assembly.
J Biol Chem
; 294(45): 16663-16671, 2019 11 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31537648
18.
MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.
Nucleic Acids Res
; 46(20): 10888-10904, 2018 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30304478
19.
Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.
Biochemistry
; 58(7): 887-899, 2019 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30614695
20.
The structure of the tetanus toxin reveals pH-mediated domain dynamics.
EMBO Rep
; 18(8): 1306-1317, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28645943