Detalhe da pesquisa
1.
Oxidative diversification of amino acids and peptides by small-molecule iron catalysis.
Nature
; 537(7619): 214-219, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27479323
2.
A multi-endpoint matched molecular pair (MMP) analysis of 6-membered heterocycles.
Bioorg Med Chem
; 25(1): 381-388, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27840138
3.
Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.
Bioorg Med Chem Lett
; 25(4): 908-13, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25582600
4.
Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning.
Nat Chem
; 16(2): 239-248, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37996732
5.
Pd(II)-catalyzed ortho- or meta-C-H olefination of phenol derivatives.
J Am Chem Soc
; 135(20): 7567-71, 2013 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23614807
6.
Small-Molecule Lead-Finding Trends across the Roche and Genentech Research Organizations.
J Med Chem
; 65(4): 3606-3615, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35138850
7.
LipMetE (Lipophilic Metabolism Efficiency) as a Simple Guide for Half-Life and Dosing Regimen Prediction of Oral Drugs.
ACS Med Chem Lett
; 13(9): 1444-1451, 2022 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36105329
8.
Divergent C-H functionalizations directed by sulfonamide pharmacophores: late-stage diversification as a tool for drug discovery.
J Am Chem Soc
; 133(18): 7222-8, 2011 May 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-21488638
9.
Quantitative pharmacokinetic/pharmacodynamic analyses suggest that the 129/SVE mouse is a suitable preclinical pharmacology model for identifying small-molecule γ-secretase inhibitors.
J Pharmacol Exp Ther
; 339(3): 922-34, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21930801
10.
Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States.
Chem Res Toxicol
; 24(9): 1345-410, 2011 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21702456
11.
Oxidative metabolism of a quinoxaline derivative by xanthine oxidase in rodent plasma.
Chem Res Toxicol
; 24(12): 2207-16, 2011 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21939274
12.
The 2nd Alpine Winter Conference on Medicinal and Synthetic Chemistry.
ChemMedChem
; 16(15): 2417-2423, 2021 08 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34114371
13.
LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits.
Sci Transl Med
; 12(540)2020 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32321864
14.
Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity.
J Am Chem Soc
; 130(39): 13110-9, 2008 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18771264
15.
Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors.
J Med Chem
; 61(8): 3626-3640, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29601185
16.
Synthesis and applications of highly functionalized 1-halo-3-substituted bicyclo[1.1.1]pentanes.
Chem Sci
; 9(23): 5295-5300, 2018 Jun 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-29997886
17.
LRRK2 activation in idiopathic Parkinson's disease.
Sci Transl Med
; 10(451)2018 07 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30045977
18.
Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.
ACS Med Chem Lett
; 9(2): 68-72, 2018 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29456790
19.
Total synthesis and antibacterial properties of carbaplatensimycin.
J Am Chem Soc
; 129(48): 14850-1, 2007 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17988130
20.
Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators.
Cell Chem Biol
; 24(7): 858-869.e5, 2017 Jul 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28669525