Detalhe da pesquisa
1.
Exploiting evolutionary trade-offs for posttreatment management of drug-resistant populations.
Proc Natl Acad Sci U S A
; 117(30): 17924-17931, 2020 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32661175
2.
Loss of protein synthesis quality control in host-restricted organisms.
Proc Natl Acad Sci U S A
; 115(49): E11505-E11512, 2018 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30455292
3.
Experimental Colitis Enhances the Rate of Antinociceptive Tolerance to Morphine via Peripheral Opioid Receptors.
J Pharmacol Exp Ther
; 370(3): 504-513, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31248978
4.
CCR5 mediates HIV-1 Tat-induced neuroinflammation and influences morphine tolerance, dependence, and reward.
Brain Behav Immun
; 69: 124-138, 2018 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29146238
5.
Morphine Tolerance and Physical Dependence Are Altered in Conditional HIV-1 Tat Transgenic Mice.
J Pharmacol Exp Ther
; 356(1): 96-105, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26542403
6.
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14ß-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.
Bioorg Med Chem
; 23(8): 1701-15, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25783191
7.
Molecular Pharmacology Profiling of Phenylfentanil and Its Analogues to Understand the Putative Involvement of an Adrenergic Mechanism in Fentanyl-Induced Respiratory Depression.
J Med Chem
; 67(1): 603-619, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38156970
8.
Systematic Structure-Activity Relationship Study of Nalfurafine Analogues toward Development of Potentially Nonaddictive Pain Management Treatments.
J Med Chem
; 67(11): 9552-9574, 2024 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38814086
9.
Structurally diverse fentanyl analogs yield differential locomotor activities in mice.
Pharmacol Biochem Behav
; 222: 173496, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36435268
10.
Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression.
Pharmacol Biochem Behav
; 226: 173572, 2023 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-37236405
11.
Structural Alterations of the "Address" Moiety of NAN Leading to the Discovery of a Novel Opioid Receptor Modulator with Reduced hERG Toxicity.
J Med Chem
; 66(1): 577-595, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36538027
12.
6ß-N-heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists.
Bioorg Med Chem Lett
; 22(14): 4731-4, 2012 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22683223
13.
Cohesin phosphorylation and mobility of SMC1 at ionizing radiation-induced DNA double-strand breaks in human cells.
Exp Cell Res
; 317(3): 330-7, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21056556
14.
Cohesin promotes the repair of ionizing radiation-induced DNA double-strand breaks in replicated chromatin.
Nucleic Acids Res
; 38(2): 477-87, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19906707
15.
Rational Design, Chemical Syntheses, and Biological Evaluations of Peripherally Selective Mu Opioid Receptor Ligands as Potential Opioid Induced Constipation Treatment.
J Med Chem
; 65(6): 4991-5003, 2022 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35255683
16.
Respiratory depressant effects of fentanyl analogs are opioid receptor-mediated.
Biochem Pharmacol
; 195: 114805, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34673011
17.
Characterization of a Potential KOR/DOR Dual Agonist with No Apparent Abuse Liability via a Complementary Structure-Activity Relationship Study on Nalfurafine Analogues.
ACS Chem Neurosci
; 13(24): 3608-3628, 2022 12 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36449691
18.
Design, Synthesis, and Biological Evaluation of NAP Isosteres: A Switch from Peripheral to Central Nervous System Acting Mu-Opioid Receptor Antagonists.
J Med Chem
; 65(6): 5095-5112, 2022 03 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35255685
19.
Sex-specific role for serotonin 5-HT2A receptor in modulation of opioid-induced antinociception and reward in mice.
Neuropharmacology
; 209: 108988, 2022 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35183539
20.
Influence of DMSO on Carbon K ultrasoft X-rays induced chromosome aberrations in V79 Chinese hamster cells.
Mutat Res
; 691(1-2): 23-6, 2010 Sep 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-20600168