Detalhe da pesquisa
1.
Synthesis and In Vitro Characterization of Selective Cannabinoid CB2 Receptor Agonists: Biological Evaluation against Neuroblastoma Cancer Cells.
Molecules
; 27(9)2022 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35566369
2.
CB1 receptor binding sites for NAM and PAM: A first approach for studying, new nbutyldiphenylcarboxamides as allosteric modulators.
Eur J Pharm Sci
; 169: 106088, 2022 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34863873
3.
Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB2R).
Front Chem
; 10: 984069, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36238097
4.
Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593.
Front Pharmacol
; 13: 919605, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36386195
5.
Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands.
J Med Chem
; 65(14): 9918-9938, 2022 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35849804
6.
Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor.
Eur J Med Chem
; 211: 113116, 2021 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33360803
7.
PSNCBAM-1 analogs: Structural evolutions and allosteric properties at cannabinoid CB1 receptor.
Eur J Med Chem
; 203: 112606, 2020 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32682199
8.
Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling.
Front Mol Neurosci
; 12: 257, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31680861
9.
Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief.
J Med Chem
; 62(1): 276-287, 2019 01 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29990428
10.
Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats.
Br J Pharmacol
; 175(1): 100-112, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29057454
11.
Enantiospecific Allosteric Modulation of Cannabinoid 1 Receptor.
ACS Chem Neurosci
; 8(6): 1188-1203, 2017 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28103441
12.
Big conductance calcium-activated potassium channel openers control spasticity without sedation.
Br J Pharmacol
; 174(16): 2662-2681, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28677901
13.
Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.
ACS Chem Neurosci
; 7(6): 776-98, 2016 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27046127
14.
Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist.
Br J Pharmacol
; 146(7): 917-26, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16205722
15.
Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB(1) receptor antagonist N-(piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716).
J Med Chem
; 45(13): 2708-19, 2002 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-12061874
16.
Evidence that (-)-7-hydroxy-4'-dimethylheptyl-cannabidiol activates a non-CB(1), non-CB(2), non-TRPV1 target in the mouse vas deferens.
Neuropharmacology
; 48(8): 1139-46, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15910889
17.
Allosteric modulation of the cannabinoid CB1 receptor.
Mol Pharmacol
; 68(5): 1484-95, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16113085
18.
Pharmacological characterization of the anandamide cyclooxygenase metabolite: prostaglandin E2 ethanolamide.
J Pharmacol Exp Ther
; 301(3): 900-7, 2002 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-12023517