Detalhe da pesquisa
1.
Design of Aminobenzothiazole Inhibitors of Rho Kinases 1 and 2 by Using Protein Kinaseâ A as a Structure Surrogate.
Chembiochem
; 19(6): 613-621, 2018 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29314498
2.
Characterization of novel small-molecule NRF2 activators: Structural and biochemical validation of stereospecific KEAP1 binding.
Biochim Biophys Acta
; 1860(11 Pt A): 2537-2552, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27474998
3.
Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition.
Commun Chem
; 6(1): 234, 2023 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37898658
4.
Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site.
Sci Rep
; 12(1): 14561, 2022 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36028520
5.
Hepatitis C NS5B polymerase inhibitors: functional equivalents for the benzothiadiazine moiety.
Bioorg Med Chem Lett
; 21(6): 1876-9, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316235
6.
Sugar phosphate activation of the stress sensor eIF2B.
Nat Commun
; 12(1): 3440, 2021 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34103529
7.
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
J Med Chem
; 64(1): 417-429, 2021 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33378180
8.
Non-peptide entry inhibitors of HIV-1 that target the gp41 coiled coil pocket.
Bioorg Med Chem Lett
; 20(2): 612-7, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20004576
9.
Accelerating pharmaceutical structure-guided drug design: a successful model.
Drug Discov Today
; 24(2): 377-381, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30448353
10.
Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer.
J Med Chem
; 62(8): 4120-4130, 2019 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30933499
11.
Hepatitis C NS5B polymerase inhibitors: 4,4-Dialkyl-1-hydroxy-3-oxo-3,4-dihydronaphthalene-3-yl benzothiadiazine derivatives.
Bioorg Med Chem Lett
; 18(14): 3887-90, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18599294
12.
Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension.
J Med Chem
; 50(13): 2990-3003, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17523610
13.
Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor.
J Med Chem
; 50(7): 1584-97, 2007 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-17343372
14.
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo.
Mol Cancer Ther
; 4(6): 977-86, 2005 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-15956255
15.
Structure of MurF from Streptococcus pneumoniae co-crystallized with a small molecule inhibitor exhibits interdomain closure.
Protein Sci
; 14(12): 3039-47, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16322581
16.
Structure-based characterization and optimization of novel hydrophobic binding interactions in a series of pyrrolidine influenza neuraminidase inhibitors.
J Med Chem
; 48(12): 3980-90, 2005 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-15943472
17.
Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors.
J Med Chem
; 48(19): 6066-83, 2005 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-16162008
18.
Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.
J Med Chem
; 47(3): 612-26, 2004 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-14736242
19.
Discovery of potent inhibitors of dihydroneopterin aldolase using CrystaLEAD high-throughput X-ray crystallographic screening and structure-directed lead optimization.
J Med Chem
; 47(7): 1709-18, 2004 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-15027862
20.
Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases.
J Med Chem
; 52(21): 6621-36, 2009 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19842661