Detalhe da pesquisa
1.
ACKR3 Antagonism Enhances the Repair of Demyelinated Lesions Through Both Immunomodulatory and Remyelinating Effects.
Neurochem Res
; 2024 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-38819698
2.
Pharmacokinetics, pharmacodynamics and safety of the novel C-X-C chemokine receptor 3 antagonist ACT-777991: Results from the first-in-human study in healthy adults.
Br J Clin Pharmacol
; 90(2): 588-599, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37752659
3.
Combination treatment of a novel CXCR3 antagonist ACT-777991 with an anti-CD3 antibody synergistically increases persistent remission in experimental models of type 1 diabetes.
Clin Exp Immunol
; 214(2): 131-143, 2023 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37458220
4.
Immunoaffinity Targeted Mass Spectrometry Analysis of Human Plasma Samples Reveals an Imbalance of Active and Inactive CXCL10 in Primary Sjögren's Syndrome Disease Patients.
J Proteome Res
; 19(10): 4196-4209, 2020 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32870689
5.
Impact of high-altitude therapy on type-2 immune responses in asthma patients.
Allergy
; 75(1): 84-94, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31267528
6.
Pharmacological Characterization of Aprocitentan, a Dual Endothelin Receptor Antagonist, Alone and in Combination with Blockers of the Renin Angiotensin System, in Two Models of Experimental Hypertension.
J Pharmacol Exp Ther
; 368(3): 462-473, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30622171
7.
Eosinophilic oesophagitis: relevance of mast cell infiltration.
Histopathology
; 73(3): 454-463, 2018 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-29772120
8.
Granulomatous lung inflammation is nanoparticle type-dependent.
Exp Lung Res
; 44(1): 25-39, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29324063
9.
Endothelin ETA Receptor Blockade, by Activating ETB Receptors, Increases Vascular Permeability and Induces Exaggerated Fluid Retention.
J Pharmacol Exp Ther
; 361(2): 322-333, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28223322
10.
Biomarker-guided clinical development of the first-in-class anti-inflammatory FPR2/ALX agonist ACT-389949.
Br J Clin Pharmacol
; 83(3): 476-486, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27730665
11.
Modeling the Effect of the Selective S1P1 Receptor Modulator Ponesimod on Subsets of Blood Lymphocytes.
Pharm Res
; 34(3): 599-609, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28028771
12.
Genetic screening for Niemann-Pick disease type C in adults with neurological and psychiatric symptoms: findings from the ZOOM study.
Hum Mol Genet
; 22(21): 4349-56, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23773996
13.
Monitoring inflammatory heterogeneity with multiple biomarkers for multidimensional endotyping of asthma.
J Allergy Clin Immunol
; 141(1): 442-445, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28987809
14.
Discovery of Clinical Candidate ACT-777991, a Potent CXCR3 Antagonist for Antigen-Driven and Inflammatory Pathologies.
J Med Chem
; 66(6): 4179-4196, 2023 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36883854
15.
Plasma neurofilament light, glial fibrillary acidic protein and lysosphingolipid biomarkers for pharmacodynamics and disease monitoring of GM2 and GM1 gangliosidoses patients.
Mol Genet Metab Rep
; 30: 100843, 2022 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-35242574
16.
A Multipurpose First-in-Human Study With the Novel CXCR7 Antagonist ACT-1004-1239 Using CXCL12 Plasma Concentrations as Target Engagement Biomarker.
Clin Pharmacol Ther
; 109(6): 1648-1659, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33406277
17.
CXCR7 Antagonism Reduces Acute Lung Injury Pathogenesis.
Front Pharmacol
; 12: 748740, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34803691
18.
Attenuation of murine sclerodermatous models by the selective S1P1 receptor modulator cenerimod.
Sci Rep
; 9(1): 658, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30679645
19.
Pharmacokinetic/Pharmacodynamic Modelling of Receptor Internalization with CRTH2 Antagonists to Optimize Dose Selection.
Clin Pharmacokinet
; 55(7): 813-821, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-26692193
20.
Comparative epitope mapping with saturation transfer difference NMR of sialyl Lewis(a) compounds and derivatives bound to a monoclonal antibody.
J Med Chem
; 48(22): 6879-86, 2005 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-16250646