Detalhe da pesquisa
1.
HBO1 is required for the maintenance of leukaemia stem cells.
Nature
; 577(7789): 266-270, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31827282
2.
Loss of tumor-derived SMAD4 enhances primary tumor growth but not metastasis following BMP4 signalling.
Cell Commun Signal
; 22(1): 248, 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38689334
3.
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Nature
; 560(7717): 253-257, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30069049
4.
Structure-guided design of a selective BCL-X(L) inhibitor.
Nat Chem Biol
; 9(6): 390-7, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23603658
5.
BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic- and antidepressant-like effects in rodents.
Neuropharmacology
; 246: 109836, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38185416
6.
Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling.
J Proteome Res
; 12(7): 3104-16, 2013 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23692254
7.
Synthesis of conformationally constrained benzoylureas as BH3-mimetics.
Org Biomol Chem
; 10(27): 5230-7, 2012 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-22648632
8.
Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors.
Bioorg Med Chem Lett
; 21(19): 5992-4, 2011 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21852129
9.
Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical library.
Antimicrob Agents Chemother
; 54(5): 1712-9, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20160053
10.
Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation.
Cell Rep
; 33(3): 108290, 2020 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33086063
11.
Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents.
J Med Chem
; 63(9): 4655-4684, 2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32118427
12.
Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity.
Antimicrob Agents Chemother
; 53(7): 2824-33, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19364854
13.
Fragment screening for a protein-protein interaction inhibitor to WDR5.
Struct Dyn
; 6(6): 064701, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31768400
14.
Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A.
J Med Chem
; 62(15): 7146-7159, 2019 08 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31256587
15.
De-novo designed library of benzoylureas as inhibitors of BCL-XL: synthesis, structural and biochemical characterization.
J Med Chem
; 57(4): 1323-43, 2014 Feb 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24456288
16.
An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.
Dis Model Mech
; 6(2): 521-9, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-22996645
17.
Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.
J Med Chem
; 56(13): 5514-40, 2013 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23767404
18.
Dihydroquinazolines as a novel class of Trypanosoma brucei trypanothione reductase inhibitors: discovery, synthesis, and characterization of their binding mode by protein crystallography.
J Med Chem
; 54(19): 6514-30, 2011 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21851087
19.
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
J Med Chem
; 54(6): 1914-26, 2011 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21366295
20.
An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets.
J Biomol Screen
; 16(10): 1196-205, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-22086725