Detalhe da pesquisa
1.
Evaluation and optimization of a microcavity plate-based human hepatocyte spheroid model for predicting clearance of slowly metabolized drug candidates.
Drug Metab Dispos
; 2024 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38777596
2.
Plasma protein-mediated uptake and contradictions to the free drug hypothesis: a critical review.
Drug Metab Rev
; 55(3): 205-238, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36971325
3.
Broad Application of CYP3A4 Liquid Chromatography-Mass Spectrometry Protein Quantification in Hepatocyte Cytochrome P450 Induction Assays Identifies Nonuniformity in mRNA and Protein Induction Responses.
Drug Metab Dispos
; 50(2): 105-113, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34857529
4.
Evaluation of Tissue Stem Cell-Derived Human Intestinal Organoids, a Physiologically Relevant Model to Evaluate Cytochrome P450 Induction in Gut.
Drug Metab Dispos
; 49(3): 245-253, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33355212
5.
Enrichment-free High-throughput Liquid Chromatography-Multiple-Reaction Monitoring Quantification of Cytochrome P450 Proteins in Plated Human Hepatocytes Direct from 96-Well Plates Enables Routine Protein Induction Measurements.
Drug Metab Dispos
; 48(7): 594-602, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32350061
6.
Metabolism and Disposition of a Novel Selective α7 Neuronal Acetylcholine Receptor Agonist ABT-126 in Humans: Characterization of the Major Roles for Flavin-Containing Monooxygenases and UDP-Glucuronosyl Transferase 1A4 and 2B10 in Catalysis.
Drug Metab Dispos
; 46(4): 429-439, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29348125
7.
Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole.
Drug Metab Dispos
; 44(8): 1424-30, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27149898
8.
Evaluation of calibration curve-based approaches to predict clinical inducers and noninducers of CYP3A4 with plated human hepatocytes.
Drug Metab Dispos
; 42(9): 1379-91, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24924386
9.
Developing an adult stem cell derived microphysiological intestinal system for predicting oral prodrug bioconversion and permeability in humans.
Lab Chip
; 24(2): 339-355, 2024 01 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38099395
10.
A Simplified Method for Determining Blood-to-Plasma Ratios in vitro and ex vivo by Matrix Matching with Blank Blood or Plasma.
Drug Metab Bioanal Lett
; 16(2): 113-120, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37592774
11.
Sequential metabolism of AMG 487, a novel CXCR3 antagonist, results in formation of quinone reactive metabolites that covalently modify CYP3A4 Cys239 and cause time-dependent inhibition of the enzyme.
Drug Metab Dispos
; 40(7): 1429-40, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22517972
12.
Case Study 3: Criticality of High-Quality Curve Fitting-"Getting a Km,app" Isn't as Simple as It May Seem.
Methods Mol Biol
; 2342: 653-664, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34272710
13.
Cardiovascular microphysiological systems (CVMPS) for safety studies - a pharma perspective.
Lab Chip
; 21(3): 458-472, 2021 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33471007
14.
Differential time- and NADPH-dependent inhibition of CYP2C19 by enantiomers of fluoxetine.
Drug Metab Dispos
; 37(4): 695-8, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19144769
15.
Evaluation of multiple in vitro systems for assessment of CYP3A4 induction in drug discovery: human hepatocytes, pregnane X receptor reporter gene, and Fa2N-4 and HepaRG cells.
Drug Metab Dispos
; 37(6): 1259-68, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19307295
16.
Towards in vitro models for reducing or replacing the use of animals in drug testing.
Nat Biomed Eng
; 2023 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38151640
17.
Selective Suppression of CYP3A4 mRNA and Enzyme Activity by Epidermal Growth Factor in Plated Human Hepatocytes.
Drug Metab Lett
; 11(2): 119-127, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29189189
18.
In Vitro Drug Metabolism Using Liver Microsomes.
Curr Protoc Pharmacol
; 74: 7.8.1-7.8.24, 2016 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27636111
19.
In vitro and pharmacophore insights into CYP3A enzymes.
Trends Pharmacol Sci
; 24(4): 161-6, 2003 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-12707001
20.
Exploring concepts of in vitro time-dependent CYP inhibition assays.
Expert Opin Drug Metab Toxicol
; 10(2): 157-74, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24256452