Detalhe da pesquisa
1.
Tropifexor plus cenicriviroc combination versus monotherapy in nonalcoholic steatohepatitis: Results from the phase 2b TANDEM study.
Hepatology
; 78(4): 1223-1239, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37162151
2.
Utility of food pellets containing 1-aminobenzotriazole for longer term in vivo inhibition of cytochrome P450 in mice.
Xenobiotica
; 49(1): 13-21, 2019 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29299977
3.
Application of Osmotic Pumps for Sustained Release of 1-Aminobenzotriazole and Inhibition of Cytochrome P450 Enzymes in Mice: Model Comparison with the Hepatic P450 Reductase Null Mouse.
Drug Metab Dispos
; 44(8): 1213-6, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27271368
4.
Application of a deuterium replacement strategy to modulate the pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a novel CRF1 antagonist.
Drug Metab Dispos
; 42(5): 954-62, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24616265
5.
1-Aminobenzotriazole modulates oral drug pharmacokinetics through cytochrome P450 inhibition and delay of gastric emptying in rats.
Drug Metab Dispos
; 42(7): 1117-24, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24727486
6.
Preclinical metabolism and pharmacokinetics of NVS-CRF38, a potent and orally bioavailable corticotropin-releasing factor receptor 1 antagonist.
Xenobiotica
; 44(10): 902-12, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-24697490
7.
Transient targeting of phosphoinositide 3-kinase acts as a roadblock in mast cells' route to allergy.
J Allergy Clin Immunol
; 132(4): 959-68, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23683463
8.
Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases.
Bioorg Med Chem
; 21(21): 6582-91, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24021582
9.
A Study to Evaluate Relative Bioavailability, Food Effect, and Pharmacodynamics of Tropifexor, a Farnesoid X Receptor Agonist, in Healthy Participants.
Clin Pharmacol Drug Dev
; 12(2): 122-131, 2023 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36495282
10.
A novel murine model of severe pulmonary arterial hypertension.
Am J Respir Crit Care Med
; 184(10): 1171-82, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21868504
11.
Drug-Drug Interaction Studies to Evaluate the Effect of Inhibition of UGT1A1 and CYP3A4 and Induction of CYP3A4 on the Pharmacokinetics of Tropifexor in Healthy Subjects.
Clin Pharmacol Drug Dev
; 11(11): 1253-1263, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35962468
12.
Pharmacokinetics of Tropifexor, a Potent Farnesoid X Receptor Agonist, in Participants With Varying Degrees of Hepatic Impairment.
J Clin Pharmacol
; 62(4): 520-531, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34738233
13.
Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.
Cancer Discov
; 12(6): 1500-1517, 2022 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35404998
14.
JDQ443, a Structurally Novel, Pyrazole-Based, Covalent Inhibitor of KRASG12C for the Treatment of Solid Tumors.
J Med Chem
; 65(24): 16173-16203, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36399068
15.
A physical properties based approach for the exploration of a 4-hydroxybenzothiazolone series of beta2-adrenoceptor agonists as inhaled long-acting bronchodilators.
Bioorg Med Chem Lett
; 20(17): 5302-7, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20655218
16.
Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure.
J Med Chem
; 63(17): 9856-9875, 2020 09 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32856916
17.
Prediction of drug clearance by glucuronidation from in vitro data: use of combined cytochrome P450 and UDP-glucuronosyltransferase cofactors in alamethicin-activated human liver microsomes.
Drug Metab Dispos
; 37(1): 82-9, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18832476
18.
Evaluation of recombinant cytochrome P450 enzymes as an in vitro system for metabolic clearance predictions.
Drug Metab Dispos
; 37(5): 1025-34, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19196847
19.
7-Azaindole-3-acetic acid derivatives: potent and selective CRTh2 receptor antagonists.
Bioorg Med Chem Lett
; 19(16): 4794-8, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19592244
20.
Structure-Based and Property-Driven Optimization of N-Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors.
J Med Chem
; 62(23): 10816-10832, 2019 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31729873