Detalhe da pesquisa
1.
Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance.
Nature
; 494(7436): 251-5, 2013 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23302800
2.
Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.
Proc Natl Acad Sci U S A
; 107(35): 15473-8, 2010 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-20713706
3.
Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data Science.
Cancer Discov
; 13(10): 2131-2149, 2023 10 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37712571
4.
STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts.
Cancer Discov
; 13(11): 2432-2447, 2023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37623743
5.
RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation.
Mol Cancer Res
; 19(6): 1063-1075, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33707308
6.
LXH254, a Potent and Selective ARAF-Sparing Inhibitor of BRAF and CRAF for the Treatment of MAPK-Driven Tumors.
Clin Cancer Res
; 27(7): 2061-2073, 2021 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33355204
7.
Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic.
J Med Chem
; 63(5): 2013-2027, 2020 03 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31059256
8.
Distinct Transcriptional Programming Drive Response to MAPK Inhibition in BRAF V600-Mutant Melanoma Patient-Derived Xenografts.
Mol Cancer Ther
; 18(12): 2421-2432, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31527224
9.
Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma.
Mol Cancer Res
; 17(1): 199-211, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30201825
10.
Tumor Intrinsic Efficacy by SHP2 and RTK Inhibitors in KRAS-Mutant Cancers.
Mol Cancer Ther
; 18(12): 2368-2380, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31439712
11.
Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF.
Cancer Res
; 78(6): 1537-1548, 2018 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29343524
12.
Phase I Dose-Escalation and -Expansion Study of the BRAF Inhibitor Encorafenib (LGX818) in Metastatic BRAF-Mutant Melanoma.
Clin Cancer Res
; 23(18): 5339-5348, 2017 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28611198
13.
Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.
J Med Chem
; 60(12): 4869-4881, 2017 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28557458
14.
Discovery of a Selective and Potent Inhibitor of Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2 (MNK1/2) Utilizing Structure-Based Drug Design.
J Med Chem
; 59(7): 3034-45, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27002243
15.
Molecular pathways: response and resistance to BRAF and MEK inhibitors in BRAF(V600E) tumors.
Clin Cancer Res
; 20(5): 1074-80, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24352648
16.
The evolution of melanoma resistance reveals therapeutic opportunities.
Cancer Res
; 73(20): 6106-10, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24097822
17.
RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation.
Cancer Cell
; 23(5): 594-602, 2013 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23680146
18.
Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging.
Sci Rep
; 3: 2859, 2013 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24091529
19.
RAF265 inhibits the growth of advanced human melanoma tumors.
Clin Cancer Res
; 18(8): 2184-98, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22351689
20.
High efficiency entrapment of antisense oligonucleotides in liposomes.
Methods Enzymol
; 387: 171-88, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-15172164