Detalhe da pesquisa
1.
HBO1 is required for the maintenance of leukaemia stem cells.
Nature
; 577(7789): 266-270, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31827282
2.
Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma.
Proc Natl Acad Sci U S A
; 116(36): 17990-18000, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31439820
3.
Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels.
Proc Natl Acad Sci U S A
; 110(29): E2724-32, 2013 Jul 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23818614
4.
Non-benzimidazole containing inhibitors of respiratory syncytial virus.
Bioorg Med Chem Lett
; 23(3): 827-33, 2013 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23265891
5.
Full efficacy with no CNS side-effects: unachievable panacea or reality? DMPK considerations in design of drugs with limited brain penetration.
Xenobiotica
; 42(1): 11-27, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-21970687
6.
Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation.
Cell Rep
; 33(3): 108290, 2020 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-33086063
7.
Pyrazole NNRTIs 1: design and initial optimisation of a novel template.
Bioorg Med Chem Lett
; 19(19): 5599-602, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19709880
8.
Pyrazole NNRTIs 4: selection of UK-453,061 (lersivirine) as a development candidate.
Bioorg Med Chem Lett
; 19(20): 5857-60, 2009 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19748778
9.
Pyrazole NNRTIs 3: optimisation of physicochemical properties.
Bioorg Med Chem Lett
; 19(19): 5603-6, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19717303
10.
Fragment screening for a protein-protein interaction inhibitor to WDR5.
Struct Dyn
; 6(6): 064701, 2019 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-31768400
11.
Organocatalytic asymmetric total synthesis of (R)-rolipram and formal synthesis of (3S,4R)-paroxetine.
Org Lett
; 10(7): 1389-91, 2008 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-18324820
12.
Organocatalytic diastereo- and enantioselective Michael addition reactions of 5-aryl-1,3-dioxolan-4-ones.
Org Lett
; 9(11): 2107-10, 2007 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-17477536
13.
Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7.
J Med Chem
; 60(16): 7029-7042, 2017 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28682065
14.
The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.
J Med Chem
; 59(22): 10084-10099, 2016 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27766865
15.
Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.
PLoS One
; 11(4): e0152405, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-27050761
16.
An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798).
J Med Chem
; 54(1): 67-77, 2011 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21128663