Detalhe da pesquisa
1.
Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1).
Bioorg Med Chem Lett
; 26(10): 2470-2474, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27055941
2.
Integrated Pharmacokinetic/Pharmacodynamic Analysis for Determining the Minimal Anticipated Biological Effect Level of a Novel Anti-CD28 Receptor Antagonist BMS-931699.
J Pharmacol Exp Ther
; 355(3): 506-15, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26442523
3.
A monovalent anti-human CD28 domain antibody antagonist: preclinical efficacy and safety.
J Immunol
; 191(9): 4599-610, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24081989
4.
An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.
J Immunol
; 184(7): 3917-26, 2010 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20190141
5.
Abatacept does not induce direct gene expression changes in antigen-presenting cells.
J Clin Immunol
; 29(4): 479-89, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19259798
6.
Circulating T Cell Subpopulations Correlate With Immune Responses at the Tumor Site and Clinical Response to PD1 Inhibition in Non-Small Cell Lung Cancer.
Front Immunol
; 9: 1613, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30123214
7.
Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.
J Med Chem
; 49(24): 6946-9, 2006 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-17125246
8.
Functional Antagonism of Human CD40 Achieved by Targeting a Unique Species-Specific Epitope.
J Mol Biol
; 428(14): 2860-79, 2016 07 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-27216500
9.
B cells from African American lupus patients exhibit an activated phenotype.
JCI Insight
; 1(9): e87310, 2016 06 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27699274
10.
Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series.
J Med Chem
; 59(6): 2820-40, 2016 Mar 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26924461
11.
Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression.
PLoS One
; 10(6): e0130490, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26098894
12.
2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses.
J Exp Med
; 211(2): 297-311, 2014 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24493803
13.
Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
J Med Chem
; 53(9): 3814-30, 2010 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-20405922
14.
Assessment of belatacept-mediated costimulation blockade through evaluation of CD80/86-receptor saturation.
Transplantation
; 87(6): 926-33, 2009 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-19300198
15.
Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction.
Clin Immunol
; 126(1): 38-47, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-17945538
16.
Abatacept binds to the Fc receptor CD64 but does not mediate complement-dependent cytotoxicity or antibody-dependent cellular cytotoxicity.
J Rheumatol
; 34(11): 2204-10, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17787038
17.
Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold.
Bioorg Med Chem Lett
; 17(7): 1908-11, 2007 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17291752
18.
De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.
Bioorg Med Chem Lett
; 15(4): 1161-4, 2005 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15686933