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1.
N Engl J Med ; 386(9): 861-868, 2022 03 03.
Artigo em Inglês | MEDLINE | ID: mdl-35235727

RESUMO

Melioidosis, caused by the bacterium Burkholderia pseudomallei, is an uncommon infection that is typically associated with exposure to soil and water in tropical and subtropical environments. It is rarely diagnosed in the continental United States. Patients with melioidosis in the United States commonly report travel to regions where melioidosis is endemic. We report a cluster of four non-travel-associated cases of melioidosis in Georgia, Kansas, Minnesota, and Texas. These cases were caused by the same strain of B. pseudomallei that was linked to an aromatherapy spray product imported from a melioidosis-endemic area.


Assuntos
Aromaterapia/efeitos adversos , Burkholderia pseudomallei/isolamento & purificação , Surtos de Doenças , Melioidose/epidemiologia , Aerossóis , Encéfalo/microbiologia , Encéfalo/patologia , Burkholderia pseudomallei/genética , COVID-19/complicações , Pré-Escolar , Evolução Fatal , Feminino , Genoma Bacteriano , Humanos , Pulmão/microbiologia , Pulmão/patologia , Masculino , Melioidose/complicações , Pessoa de Meia-Idade , Filogenia , Choque Séptico/microbiologia , Estados Unidos/epidemiologia
2.
Am J Physiol Lung Cell Mol Physiol ; 320(5): L785-L790, 2021 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-33655765

RESUMO

Noninvasive sampling of the distal airspace in patients with acute respiratory distress syndrome (ARDS) has long eluded clinical and translational researchers. We recently reported that fluid collected from heat moisture exchange (HME) filters closely mirrors fluid directly aspirated from the distal airspace. In the current study, we sought to determine fluid yield from different HME types, optimal HME circuit dwell time, and reliability of HME fluid in reflecting the distal airspace. We studied fluid yield from four different filter types by loading increasing volumes of saline and measuring volumes of fluid recovered. We collected filters after 1, 2, and 4 h of dwell time for measurement of fluid volume and total protein from 13 subjects. After identifying 4 h as the optimal dwell time, we measured total protein and IgM in HME fluid from 42 subjects with ARDS and nine with hydrostatic pulmonary edema (HYDRO). We found that the fluid yield varies greatly by filter type. With timed sample collection, fluid recovery increased with increasing circuit dwell time with a median volume of 2.0 mL [interquartile range (IQR) 1.2-2.7] after 4 h. Total protein was higher in the 42 subjects with ARDS compared with nine with HYDRO [median 708 µg/mL (IQR 244-2017) vs. 364 µg/mL (IQR 136-578), P = 0.047], confirming that total protein concentration in HME is higher in ARDS compared with hydrostatic edema. These studies establish a standardized HME fluid collection protocol and confirm that HME fluid analysis is a novel noninvasive tool for the study of the distal airspace in ARDS.


Assuntos
Técnicas de Diagnóstico do Sistema Respiratório/normas , Temperatura Alta , Umidade , Edema Pulmonar/diagnóstico , Respiração Artificial/métodos , Síndrome do Desconforto Respiratório/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Testes Respiratórios , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Edema Pulmonar/fisiopatologia , Síndrome do Desconforto Respiratório/fisiopatologia
3.
Emerg Infect Dis ; 26(12): 2815-2824, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-33219643

RESUMO

The zoonotic disease anthrax is endemic to most continents. It is a disease of herbivores that incidentally infects humans through contact with animals that are ill or have died from anthrax or through contact with Bacillus anthracis-contaminated byproducts. In the United States, human risk is primarily associated with handling carcasses of hoofstock that have died of anthrax; the primary risk for herbivores is ingestion of B. anthracis spores, which can persist in suitable alkaline soils in a corridor from Texas through Montana. The last known naturally occurring human case of cutaneous anthrax associated with livestock exposure in the United States was reported from South Dakota in 2002. Texas experienced an increase of animal cases in 2019 and consequently higher than usual human risk. We describe the animal outbreak that occurred in southwest Texas beginning in June 2019 and an associated human case. Primary prevention in humans is achieved through control of animal anthrax.


Assuntos
Antraz , Bacillus anthracis , Dermatopatias Bacterianas , Animais , Antraz/epidemiologia , Antraz/prevenção & controle , Surtos de Doenças/prevenção & controle , Humanos , Dermatopatias Bacterianas/epidemiologia , Texas/epidemiologia , Zoonoses/epidemiologia
7.
Pathogens ; 11(8)2022 07 23.
Artigo em Inglês | MEDLINE | ID: mdl-35894048

RESUMO

Abstract Bacillus cereus group bacteria containing the anthrax toxin genes can cause fatal anthrax pneumonia in welders. Two welder's anthrax cases identified in 2020 were investigated to determine the source of each patient's exposure. Environmental sampling was performed at locations where each patient had recent exposure to soil and dust. Samples were tested for the anthrax toxin genes by real-time PCR, and culture was performed on positive samples to identify whether any environmental isolates matched the patient's clinical isolate. A total of 185 environmental samples were collected in investigation A for patient A and 108 samples in investigation B for patient B. All samples from investigation B were real-time PCR-negative, but 14 (8%) samples from investigation A were positive, including 10 from patient A's worksite and 4 from his work-related clothing and gear. An isolate genetically matching the one recovered from patient A was successfully cultured from a worksite soil sample. All welder's anthrax cases should be investigated to determine the source of exposure, which may be linked to their worksite. Welding and metalworking employers should consider conducting a workplace hazard assessment and implementing controls to reduce the risk of occupationally associated illnesses including welder's anthrax.

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