Detalhe da pesquisa
1.
DNA polymerase θ protects leukemia cells from metabolically induced DNA damage.
Blood
; 141(19): 2372-2389, 2023 05 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36580665
2.
Tyrosine kinase inhibitor-induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors.
Blood
; 132(1): 67-77, 2018 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29784639
3.
Novel allosteric PARP1 inhibitors for the treatment of BRCA-deficient leukemia.
Med Chem Res
; 29(6): 962-978, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-33071527
4.
Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination-Deficient Leukemia Cells.
Mol Cancer Res
; 21(10): 1017-1022, 2023 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37358557
5.
Polθ promotes the repair of 5'-DNA-protein crosslinks by microhomology-mediated end-joining.
Cell Rep
; 34(10): 108820, 2021 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33691100
6.
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors.
Cancer Res
; 81(19): 5089-5101, 2021 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34215619
7.
Publisher Correction: Molecular basis of microhomology-mediated end-joining by purified full-length Polθ.
Nat Commun
; 11(1): 1831, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32273507
8.
TGFßR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment.
Cell Rep
; 33(1): 108221, 2020 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33027668
9.
RAD52 as a Potential Target for Synthetic Lethality-Based Anticancer Therapies.
Cancers (Basel)
; 11(10)2019 Oct 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31615159
10.
Molecular basis of microhomology-mediated end-joining by purified full-length Polθ.
Nat Commun
; 10(1): 4423, 2019 09 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31562312
11.
Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells.
Cell Rep
; 23(11): 3127-3136, 2018 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29898385
12.
IGH/MYC Translocation Associates with BRCA2 Deficiency and Synthetic Lethality to PARP1 Inhibitors.
Mol Cancer Res
; 15(8): 967-972, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28634224