1.
Bioorg Med Chem Lett
; 15(13): 3257-62, 2005 Jul 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15923115
RESUMO
Twenty-four 4-hydroxypyrone derivatives were synthesized with a facile synthetic method to develop novel HIV protease inhibitors. Most of them were shown to display good antiviral activities in SIV-infected CEM cells. The introduction of alpha-naphthylmethyl group to C-6 of 5,6-dihydropyran-2-ones led to an effective antiviral compound that showed an EC(50) value at 1.7 microM with a therapeutic index of 46.