1.
Bioorg Med Chem Lett
; 16(19): 4994-5000, 2006 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16904318
RESUMO
The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists. Structure-activity relationships and efforts to optimize pharmacokinetic properties are detailed along with the demonstration of the effectiveness of an MCH R1 antagonist in an animal model of obesity.