Detalhe da pesquisa
1.
Pharmacological Characterization of a Potent Inhibitor of Autotaxin in Animal Models of Inflammatory Bowel Disease and Multiple Sclerosis.
J Pharmacol Exp Ther
; 359(1): 207-14, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27516465
2.
Intraarticular Matrix Metalloproteinases and Aggrecan Degradation Are Elevated After Articular Fracture.
Clin Orthop Relat Res
; 473(10): 3280-8, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26162411
3.
A Monovalent Fab Affinity-Capture and Elution Bridging Immunoassay Overcomes Rheumatoid Factor Interference while Accurately Detecting Antidrug Antibodies.
J Appl Lab Med
; 8(5): 896-908, 2023 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37473444
4.
MMP-13 selective isonipecotamide alpha-sulfone hydroxamates.
Bioorg Med Chem Lett
; 20(12): 3561-4, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20529685
5.
Orally bioavailable dual MMP-1/MMP-14 sparing, MMP-13 selective alpha-sulfone hydroxamates.
Bioorg Med Chem Lett
; 20(12): 3557-60, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20529684
6.
Development and validation of a novel immunogenicity assay to detect anti-drug and anti-PEG antibodies simultaneously with high sensitivity.
J Immunol Methods
; 486: 112856, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32916164
7.
Investigation of pre-existing reactivity to biotherapeutics can uncover potential immunogenic epitopes and predict immunogenicity risk.
MAbs
; 11(5): 861-869, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-31099718
8.
Development and characterization of a novel ELISA based assay for the quantitation of sub-nanomolar levels of neoepitope exposed NITEGE-containing aggrecan fragments.
J Immunol Methods
; 328(1-2): 162-8, 2007 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17942111
9.
A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose.
J Med Chem
; 60(13): 5933-5939, 2017 07 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28613895
10.
Use of Osmotic Pumps to Establish the Pharmacokinetic-Pharmacodynamic Relationship and Define Desirable Human Performance Characteristics for Aggrecanase Inhibitors.
J Med Chem
; 59(12): 5810-22, 2016 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27194201
11.
Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.
ACS Med Chem Lett
; 7(9): 857-61, 2016 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27660691
12.
Synthesis and structure-activity relationships of beta- and alpha-piperidine sulfone hydroxamic acid matrix metalloproteinase inhibitors with oral antitumor efficacy.
J Med Chem
; 48(21): 6713-30, 2005 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16220987
13.
Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.
J Med Chem
; 57(24): 10476-85, 2014 Dec 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25415648
14.
Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease.
J Med Chem
; 53(18): 6653-80, 2010 Sep 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20726512