Glucocorticoid-Regulated Kinase CAMKIγ in the Central Amygdala Controls Anxiety-like Behavior in Mice.

The expression of the Calcium/Calmodulin-Dependent Protein Kinase I gamma (encoded by the Camk1g gene) depends on the activation of glucocorticoid receptors (GR) and is strongly regulated by stress. Since Camk1g is primarily expressed in neuronal cells of the limbic system in the brain, we hypothesized that it could be involved in signaling mechanisms that underlie the adaptive or maladaptive responses to stress. Here, we find that restraint-induced stress and the GR agonist dexamethasone robustly increase the expression of Camk1g in neurons of the amygdalar nuclei in the mouse brain. To assess the functional role of Camk1g expression, we performed a virally induced knock-down of the transcript. Mice with bilateral amygdala-specific Camk1g knock-down showed increased anxiety-like behaviors in the light-dark box, and an increase in freezing behavior after fear-conditioning, but normal spatial working memory during exploration of a Y-maze. Thus, we confirm that Camk1g is a neuron-specific GR-regulated transcript, and show that it is specifically involved in behaviors related to anxiety, as well as responses conditioned by aversive stimuli.

COVID-19-related social isolation and symptoms of depression and anxiety in young men in Poland: Does insomnia mediate the relationship?

The need for physical distancing due to COVID-19 mitigation efforts forced prolonged social isolation, which may affect sleep and lead to mental health problems. Previous research has shown that young adults are particularly vulnerable to psychological stress caused by social isolation, the negative psychological impact of the pandemic, and greater frequency and severity of sleep problems. Therefore, the main goal of the present study was to examine whether insomnia could constitute a mediation mechanism that explains the relationship between social isolation experienced during the COVID-19 pandemic and mental health outcomes (depression and anxiety) reported up to 1.5 years later. The study was conducted among young (M±SD; 24.08±3.75) men (N = 1025) in Poland. Data were collected by means of self-report questionnaires, including The Social Isolation Index, The Athens Insomnia Scale, The State-Trait Anxiety Inventory (STAI-S) and Beck's Depression Inventory (BDI-II). The results show that insomnia mediates the relationships between social isolation and both anxiety and depression. The current findings emphasize the role of insomnia in the relationships between social isolation experienced during COVID-19 and negative emotional states. From a clinical perspective, the results suggest that implementing therapeutic components that address social isolation in insomnia treatment programs may prevent the development of depression and anxiety symptoms among young men.

Differences in psychological distress, resilience and cognitive emotional regulation strategies in adults during the Coronavirus pandemic: A cross-cultural study of Poland and Spain

El objetivo de este estudio transcultural fue analizar las diferencias en resiliencia, estrategias de regulación cognitiva de las emociones (CERS) y distress psicológico durante la pandemia del COVID-19 en Polonia y España. Método. Se realizó una encuesta online en una muestra de 1,182 adultos. Se llevó a cabo un análisis MANOVA para examinar las diferencias en las variables estudiadas entre estos países. Esto fue seguido de un análisis MANCOVA controlando el sexo y la edad. Se realizaron análisis de regresión lineal segmentados por país con el fin de identificar modelos predictivos de distrés psicológico. Resultados. La población polaca se caracterizó por niveles más altos de ansiedad, menos resiliencia y más uso de CERS desadaptativas durante el confinamiento. La población española sufrió más estrés pero utilizó CERS adaptativas y fue más resiliente. La edad y el sexo femenino aparecieron como factores de riesgo de malestar psicológico en España. Se encontró que los modelos de predicción de distrés psicológico fueron diferentes en ambos países: las CERS adaptativas fueron predictivas en España y la resiliencia fue predictiva en Polonia. Conclusiones. Este estudio podría guiar en iniciativas para la promoción del bienestar psicológico como vía para prevenir trastornos psicopatológicos durante la pandemia.(AU)

Background.The objective of this cross-cultural study was to ana-lyze the differences in resilience, cognitive emotion regulation strategies (CERS), as well as psychological distress during the COVID-19 pandemic between Poland and Spain. Method.An online survey was conducted on a sample of 1,182 adults. A MANOVA analysis was carried out to examine the differences in the studied variables between these countries. This was followed by MANCOVA analysis to control for gender and age. Linear re-gression analyses segmented by country were conducted in order to identi-fy psychological distress prediction models. Results.Polish population was characterized by higher levels of anxiety, less resilience and more maladap-tive CERS during the lockdown. Spanish population was more affected by stress but used more adaptable CERS and was more resilient. Age and fe-male gender appeared as risk factors of psychological distress in Spain. The psychological distress prediction models were found to be different be-tween both countries: adaptive CERS was predictive only in Spain, and re-silience was predictive only in Poland. Conclusions.This study could guide in initiatives for the promotion of psychological well-being as a way to pre-vent psychopathological disorders during the pandemic.(AU)