Detalhe da pesquisa
1.
Switching the three-component Biginelli-like reaction conditions for the regioselective synthesis of new 2-amino[1,2,4]triazolo[1,5-a]pyrimidines.
Org Biomol Chem
; 22(4): 767-783, 2024 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38167738
2.
Privileged Scaffolds for Potent and Specific Inhibitors of Mono-ADP-Ribosylating PARPs.
Molecules
; 28(15)2023 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37570820
3.
C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors.
J Enzyme Inhib Med Chem
; 35(1): 584-597, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31992093
4.
Structural Modifications of the Quinolin-4-yloxy Core to Obtain New Staphylococcus aureus NorA Inhibitors.
Int J Mol Sci
; 21(19)2020 Sep 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32987835
5.
1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity.
Molecules
; 25(5)2020 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32151066
6.
From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors.
J Enzyme Inhib Med Chem
; 34(1): 55-74, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30362381
7.
Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives.
Org Biomol Chem
; 15(37): 7944-7955, 2017 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28902220
8.
The 6-Aminoquinolone WC5 inhibits different functions of the immediate-early 2 (IE2) protein of human cytomegalovirus that are essential for viral replication.
Antimicrob Agents Chemother
; 58(11): 6615-26, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25155603
9.
Accounting for target flexibility and water molecules by docking to ensembles of target structures: the HCV NS5B palm site I inhibitors case study.
J Chem Inf Model
; 54(2): 481-97, 2014 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-23952658
10.
Exploiting the anti-HIV 6-desfluoroquinolones to design multiple ligands.
Bioorg Med Chem
; 22(17): 4658-66, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25127466
11.
Synthetically accessible de novo design using reaction vectors: Application to PARP1 inhibitors.
Mol Inform
; 43(4): e202300183, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38258328
12.
[1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes.
J Med Chem
; 66(2): 1301-1320, 2023 01 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36598465
13.
Triazolopyrimidine Nuclei: Privileged Scaffolds for Developing Antiviral Agents with a Proper Pharmacokinetic Profile.
Curr Med Chem
; 29(8): 1379-1407, 2022 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34042030
14.
Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules.
J Med Chem
; 65(11): 7532-7560, 2022 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35608571
15.
New C-6 functionalized quinoline NorA inhibitors strongly synergize with ciprofloxacin against planktonic and biofilm growing resistant Staphylococcus aureus strains.
Eur J Med Chem
; 241: 114656, 2022 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35963131
16.
Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15.
Eur J Med Chem
; 237: 114362, 2022 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35500474
17.
From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia.
Pharmaceutics
; 14(11)2022 Oct 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36365115
18.
Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity.
ACS Med Chem Lett
; 13(5): 855-864, 2022 May 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35571875
19.
Inhibition of Influenza Virus Polymerase by Interfering with Its Protein-Protein Interactions.
ACS Infect Dis
; 7(6): 1332-1350, 2021 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33044059
20.
1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors.
Eur J Med Chem
; 221: 113494, 2021 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33962311