[Accelerated partial breast irradiation with three-dimensional conformal external beam radiotherapy following breast-conserving surgery -- preliminary results of a phase II clinical study]. / Akcelerált parciális konformális külso emlobesugárzás emlomegtartó mûtét után - fázis II prospektív klinikai vizsgálat elozetes eredményei.

The aim of the study was to implement accelerated partial breast irradiation (APBI) by means of three-dimensional conformal radiotherapy (3D-CRT) following breast-conserving surgery (BCS) for early-stage breast cancer. Between December 2006 and February 2011, in 45 cases of low-risk, stage I-II breast cancer the tumour bed was marked with titanium clips during BCS. Postoperative APBI was given by means of 3D-CRT using 3 to 5 non-coplanar fields. The total dose of APBI was 36.9 Gy (9 x 4.1 Gy) using a twice-a-day fractionation over 5 consecutive days. Early and late radiation side effects and cosmetic results were analysed for the first 30 patients with a minimum follow-up of 1 year. At a mean follow-up of 25.2 months neither loco-regional nor distant failure was observed. Excellent, good, fair, and poor cosmetic outcome was detected in 10 (33.3%), 16 (53.4%), 4 (13.3%), and 0 (0%) patients, respectively. Grade 2 or worse acute side effect was not observed. Grade 1 fibrosis, grade 2 teleangiectasia and asymptomatic fat necrosis occurred in 4 (13.3%), 1 (3.3%) and 5 (16.7%) patients, respectively. No grade 3-4 late side effects were detected. 3D-CRT is a reproducible and feasible technique for the delivery of APBI following conservative surgery for the treatment of low-risk, early-stage invasive breast carcinoma. The preliminary results are promising, early- and mid-term radiation side effects are rare, and cosmetic results are excellent.

[Chemo- and radiotherapy of germ cell testicular cancer in the literature]. / Csírasejtes heredaganatok kemo- és sugárterápiája az irodalom tükrében.

The study reviews the incidence, histologic types and prognostic factors of testicular cancer. The measurement of tumor-marker levels before castration determine the further activity regarding the data of imagings. The authors explain the treatment of seminoma and non-seminoma by stages. Carboplatin monotherapy is equivalent to the irradiation in early seminoma cases. Nowadays applied second and third line chemotherapies are reviewed. It is necessary to take into consideration not only the remission rate but also the late toxicity during the complex treatment of testicular germ cell cancer.