Assuntos
Doença Arterial Periférica/terapia , Medicina Regenerativa/métodos , Medicina Regenerativa/tendências , Arteriosclerose Obliterante/terapia , Autoenxertos , Transplante de Medula Óssea , Sistemas de Liberação de Medicamentos , Fatores de Crescimento de Fibroblastos/administração & dosagem , Gelatina , Ondas de Choque de Alta Energia , Humanos , Hidrogel de Polietilenoglicol-Dimetacrilato , Injeções Intramusculares , Esclerodermia Difusa/terapia , Células-Tronco , Tromboangiite Obliterante/terapiaRESUMO
BACKGROUND: A simple list of diagnostic criteria for atopic dermatitis for use in epidemiological studies was developed by a U.K. working party. This list served well for both hospital patients with skin diseases and in general population within the U.K. OBJECTIVES: To validate the U.K. diagnostic criteria in Japanese elementary schoolchildren, we collected the questionnaires on regular health checkups, which had been completed by parents of schoolchildren in 2001/2002 and 2004/2005. METHODS: Elementary schoolchildren were examined by dermatologists in eight areas (16,152 children) in 2001/2002 and in three areas (3849 children) in 2004/2005. The questionnaire was distributed to the parents 2 weeks before the skin examination, completed by the parents and collected after the survey. RESULTS: In 2002/2002 comparing the U.K. diagnostic criteria with the findings on clinical examination used as the reference standard, the U.K. criteria (1-year prevalence measure) showed a sensitivity of 71.8%, specificity of 89.3% and positive predictive value of 44.7%. In 2004/2005 we confirmed that the U.K. criteria for a point prevalence measure showed a higher positive predictive value (59.9%) compared with that for 1-year prevalence measure (49.3%). CONCLUSION: Now that we know the sensitivity and specificity of the U.K. criteria in the population examined in this study, we will be able in the near future to estimate the prevalence of atopic dermatitis in a similar population with reverse operation by questionnaires alone using these criteria without examination by dermatologists. Therefore, the validation study of U.K. criteria could be useful for future epidemiologic surveys.
Assuntos
Dermatite Atópica/diagnóstico , Dermatite Atópica/epidemiologia , Criança , Serviços de Saúde Comunitária , Dermatologia/métodos , Humanos , Japão , Valor Preditivo dos Testes , Prevalência , Padrões de Referência , Instituições Acadêmicas , Sensibilidade e Especificidade , Inquéritos e Questionários , Reino UnidoAssuntos
Autoanticorpos/análise , Moléculas de Adesão Celular/imunologia , Imunoglobulina G/imunologia , Penfigoide Bolhoso/complicações , Psoríase/complicações , Adulto , Humanos , Masculino , Penfigoide Bolhoso/imunologia , Penfigoide Bolhoso/patologia , Psoríase/imunologia , Psoríase/patologia , CalininaAssuntos
Síndrome de Bloom , Adenosina Trifosfatases/genética , Síndrome de Bloom/diagnóstico , Síndrome de Bloom/genética , Síndrome de Bloom/fisiopatologia , Síndrome de Bloom/terapia , DNA Helicases/genética , Reparo do DNA , Diagnóstico Diferencial , Humanos , Mutação , Prognóstico , RecQ HelicasesRESUMO
A 46-year-old man was admitted to our hospital for further evaluation of a hypoechogenic mass in the pancreatic body. He had no history of hypertension, pancreatitis, abdominal trauma, or portal hypertension. He had no abdominal symptoms. A contrast-enhanced CT scan demonstrated a hypodense, round shaped mass. EUS and MRI also showed it to be a pancreatic mass. Because of the tumor size of more than 30mm and the possibility of malignancy, distal pancreatectomy was performed. Microscopic findings showed the mass was the dissection of the proximal splenic artery. The true lumen of the dissecting aneurysm was occluded and the false lumen developed fusiform dilatation. Moreover, microscopic findings revealed the rupture of the false lumen complicated by pseudoaneurysm. We finally diagnosed the lesion simulating a pancreatic tumor as the pseudoaneurysm of the splenic artery.