Detalhe da pesquisa
1.
Evaluation of Icotinib as a Potent and Selective Inhibitor of Aldehyde Oxidase for Reaction Phenotyping in Human Hepatocytes.
Drug Metab Dispos
; 52(6): 565-573, 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38565303
2.
The Drug-Drug Interaction Between Erlotinib and OSI-930 is Mediated Through Aldehyde Oxidase Inhibition.
Drug Metab Dispos
; 2024 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38889967
3.
Probe Substrate Dependencies in CYP3A4 Allosteric Inhibition: A Novel Molecular Mechanism Involving F-F' Loop Perturbations.
J Chem Inf Model
; 64(6): 2058-2067, 2024 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38457234
4.
Identification of Infigratinib as a Potent Reversible Inhibitor and Mechanism-Based Inactivator of CYP2J2: Nascent Evidence for a Potential In Vivo Metabolic Drug-Drug Interaction with Rivaroxaban.
J Pharmacol Exp Ther
; 382(2): 123-134, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35640957
5.
Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of CYP3A.
Drug Metab Dispos
; 50(7): 931-941, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35512804
6.
Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A.
Drug Metab Dispos
; 50(5): 529-540, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35153194
7.
Febuxostat and its major acyl glucuronide metabolite are potent inhibitors of organic anion transporter 3: Implications for drug-drug interactions with rivaroxaban.
Biopharm Drug Dispos
; 43(2): 57-65, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35088420
8.
Mechanism-Based Inactivation of Cytochrome P450 3A4 by Benzbromarone.
Mol Pharmacol
; 99(4): 266-276, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33436520
9.
Differential Reversible and Irreversible Interactions between Benzbromarone and Human Cytochrome P450s 3A4 and 3A5.
Mol Pharmacol
; 100(3): 224-236, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34210765
10.
Infigratinib Is a Reversible Inhibitor and Mechanism-Based Inactivator of Cytochrome P450 3A4.
Drug Metab Dispos
; 49(9): 856-868, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34326139
11.
Mechanism-Based Inactivation of Cytochrome P450 3A4 and 3A5 by the Fibroblast Growth Factor Receptor Inhibitor Erdafitinib.
Chem Res Toxicol
; 34(7): 1800-1813, 2021 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34189909
12.
Combination Bacillus Calmette-Guérin and indoleamine 2,3-dioxygenase 1 inhibitor therapy of murine orthotopic bladder cancer.
BJU Int
; 126(5): 554-556, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32770708
13.
Characterization and Applications of Permeabilized Hepatocytes in Drug Discovery.
AAPS J
; 26(3): 38, 2024 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38548986
14.
Characterization of CYP3A5 Selective Inhibitors for Reaction Phenotyping of Drug Candidates.
AAPS J
; 26(2): 26, 2024 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38366061
15.
Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes.
AAPS J
; 26(3): 36, 2024 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38546903
16.
Tissue-Specific microRNA Expression Profiling to Derive Novel Biomarkers for the Diagnosis and Subtyping of Small B-Cell Lymphomas.
Cancers (Basel)
; 15(2)2023 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36672402
17.
Quantification of the irreversible fibroblast growth factor receptor inhibitor futibatinib by UPLC-MS/MS: Application to the metabolic stability assay in human liver microsomes for the estimation of its in vitro hepatic intrinsic clearance.
J Pharm Biomed Anal
; 214: 114731, 2022 May 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-35325798
18.
Metabolic activation of drugs by cytochrome P450 enzymes: Biochemical insights into mechanism-based inactivation by fibroblast growth factor receptor inhibitors and chemical approaches to attenuate reactive metabolite formation.
Biochem Pharmacol
; 206: 115336, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36332675
19.
Rational deuteration of dronedarone attenuates its toxicity in human hepatic HepG2 cells.
Toxicol Res (Camb)
; 11(2): 311-324, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35510231
20.
Atypical kinetics of cytochrome P450 enzymes in pharmacology and toxicology.
Adv Pharmacol
; 95: 131-176, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35953154