Detalhe da pesquisa
1.
Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA.
Immunity
; 45(4): 737-748, 2016 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27742543
2.
Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9.
Nature
; 520(7549): 702-5, 2015 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-25686612
3.
Small-molecule inhibition of TLR8 through stabilization of its resting state.
Nat Chem Biol
; 14(1): 58-64, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29155428
4.
Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8.
Proc Natl Acad Sci U S A
; 113(11): 3012-7, 2016 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26929371
5.
Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists.
Nat Commun
; 12(1): 4351, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34272380
6.
Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.
J Med Chem
; 63(8): 4117-4132, 2020 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32233366
7.
Small-Molecule TLR8 Antagonists via Structure-Based Rational Design.
Cell Chem Biol
; 25(10): 1286-1291.e3, 2018 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-30100350
8.
Identification of a Human Toll-Like Receptor (TLR) 8-Specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles.
J Med Chem
; 59(7): 3311-30, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26966993
9.
Toll-like receptor 8 senses degradation products of single-stranded RNA.
Nat Struct Mol Biol
; 22(2): 109-15, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25599397
10.
Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity.
J Med Chem
; 58(19): 7833-49, 2015 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26351878
11.
The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes.
PLoS One
; 10(8): e0134640, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26274907
12.
Structure and function of toll-like receptor 8.
Microbes Infect
; 16(4): 273-82, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24513445
13.
Structure-based design of novel human Toll-like receptor 8 agonists.
ChemMedChem
; 9(4): 719-23, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24474703
14.
Determinants of activity at human Toll-like receptors 7 and 8: quantitative structure-activity relationship (QSAR) of diverse heterocyclic scaffolds.
J Med Chem
; 57(19): 7955-70, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25192394
15.
Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands.
Science
; 339(6126): 1426-9, 2013 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23520111