A hypothalamic novelty signal modulates hippocampal memory.

The ability to recognize information that is incongruous with previous experience is critical for survival. Novelty signals have therefore evolved in the mammalian brain to enhance attention, perception and memory1,2. Although the importance of regions such as the ventral tegmental area3,4 and locus coeruleus5 in broadly signalling novelty is well-established, these diffuse monoaminergic transmitters have yet to be shown to convey specific information on the type of stimuli that drive them. Whether distinct types of novelty, such as contextual and social novelty, are differently processed and routed in the brain is unknown. Here we identify the supramammillary nucleus (SuM) as a novelty hub in the hypothalamus6. The SuM region is unique in that it not only responds broadly to novel stimuli, but also segregates and selectively routes different types of information to discrete cortical targets-the dentate gyrus and CA2 fields of the hippocampus-for the modulation of mnemonic processing. Using a new transgenic mouse line, SuM-Cre, we found that SuM neurons that project to the dentate gyrus are activated by contextual novelty, whereas the SuM-CA2 circuit is preferentially activated by novel social encounters. Circuit-based manipulation showed that divergent novelty channelling in these projections modifies hippocampal contextual or social memory. This content-specific routing of novelty signals represents a previously unknown mechanism that enables the hypothalamus to flexibly modulate select components of cognition.

Climate mitigation potentials of teleworking are sensitive to changes in lifestyle and workplace rather than ICT usage.

The growth in remote and hybrid work catalyzed by the COVID-19 pandemic could have significant environmental implications. We assess the greenhouse gas emissions of this transition, considering factors including information and communication technology, commuting, noncommute travel, and office and residential energy use. We find that, in the United States, switching from working onsite to working from home can reduce up to 58% of work's carbon footprint, and the impacts of IT usage are negligible, while office energy use and noncommute travel impacts are important. Our study also suggests that achieving the environmental benefits of remote work requires proper setup of people's lifestyle, including their vehicle choice, travel behavior, and the configuration of home and work environment.

Geogenic Phosphorus Enrichment in Groundwater due to Anaerobic Methane Oxidation-Coupled Fe(III) Oxide Reduction.

Accumulation of geogenic phosphorus (P) in groundwater is an emerging environmental concern, which is closely linked to coupled processes involving FeOOH and organic matter under methanogenic conditions. However, it remains unclear how P enrichment is associated with methane cycling, particularly the anaerobic methane oxidation (AMO). This study conducted a comprehensive investigation of carbon isotopes in dissolved inorganic carbon (DIC), CO2, and CH4, alongside Fe isotopes, microbial communities, and functions in quaternary aquifers of the central Yangtze River plain. The study found that P concentrations tended to increase with Fe(II) concentrations, δ56Fe, and δ13C-DIC, suggesting P accumulation due to the reductive dissolution of FeOOH under methanogenic conditions. The positive correlations of pmoA gene abundance versus δ13C-CH4 and Fe concentrations versus δ13C-CH4, and the prevalent presence of Candidatus_Methanoperedens, jointly demonstrated the potential significance of Fe(III)-mediated AMO process (Fe-AMO) alongside traditional methanogenesis. The increase of P concentration with δ13C-CH4 value, pmoA gene abundance, and Fe concentration suggested that the Fe-AMO process facilitated P enrichment in groundwater. Redundancy analysis confirmed this assertion, identifying P concentration as the primary determinant and the cooperative influence of Fe-AMO microorganisms such as Candidatus_Methanoperedens and Geobacter on P enrichment. Our work provided new insights into P dynamics in subsurface environments.

Determination of high-risk factors and related spatially influencing variables of heavy metals in groundwater.

Identifying high-risk factors (heavy metals (HMs) and pollution sources) by coupling receptor models and health risk assessment model (HRA) is a novel approach within the field of risk assessment. However, this coupled model ignores the contribution of spatial differentiation to high-risk factors, resulting in the assessment being subjective. Taking Dongting Plain (DTP) as an example, a coupling framework by jointly using the positive matrix factorization model (PMF), HRA, Monte Carlo simulation, and geo-detector was developed, aiming to identify high-risk factors in groundwater, and further explore key environmental variables influencing the spatial heterogeneity of high-risk factors. The results showed that at least 82.86 % of non-carcinogenic risks and 97.41 % of carcinogenic risks were unacceptable for people of all ages, especially infants and children. According to the relationships among HMs, pollution sources, and health risks, As and natural sources were defined as high-risk HMs and sources, respectively. The interactions among Holocene thickness, oxidation-reduction potential, and dissolved organic carbon emerged as the primary drivers of spatial variability in high-risk factors, with their combined explanatory power reaching up to 74%. This proposed framework provides a scientific reference for future studies and a practical reference for environmental authorities in developing effective pollution management measures.

Coupled Processes Involving Organic Matter and Fe Oxyhydroxides Control Geogenic Phosphorus Enrichment in Groundwater Systems: New Evidence from FT-ICR-MS and XANES.

The enrichment of geogenic phosphorus (P) in groundwater systems threatens environmental and public health worldwide. Two significant factors affecting geogenic P enrichment include organic matter (OM) and Fe (oxyhydr)oxide (FeOOH). However, due to variable reactivities of OM and FeOOH, variable strategies of their coupled influence controlling P enrichment in groundwater systems remain elusive. This research reveals that when the depositional environment is enriched in more labile aliphatic OM, its fermentation is coupled with the reductive dissolution of both amorphous and crystalline FeOOHs. When the depositional environment is enriched in more recalcitrant aromatic OM, it largely relies on crystalline FeOOH acting concurrently as electron acceptors while serving as "conduits" to help itself stimulate degradation and methanogenesis. The main source of geogenic P enriched by these two different coupled processes is different: the former is P-containing OM, which mainly contained unsaturated aliphatic compounds and highly unsaturated-low O compounds, and the latter is P associated with crystalline FeOOH. In addition, geological setting affects the deposition rate of sediments, which can alter OM degradation/preservation, and subsequently affects geochemical conditions of geogenic P occurrence. These findings provide new evidence and perspectives for understanding the hydro(bio)geochemical processes controlling geogenic P enrichment in alluvial-lacustrine aquifer systems.

Dissolved organic matter characterization in high and low ammonium groundwater of Dongting Plain, central China.

High levels of ammonium in groundwater is a potential threat to drinking water security and ecological status. The role of dissolved organic matter (DOM) in mobilization of natural ammonium in groundwater is crucial but the intrinsic link between them has still been poorly understood. This study used high-pressure size exclusion chromatography (HPSEC) and fluorescence excitataion-emission-matrix spectra (EEMs) with parallel factor analysis (PARAFAC) to elucidate the influence of DOM characteristics in groundwater systems having contrastive ammonium levels in Dongting Plain, central Yangtze River. The results indicate that NH4+-N concentration in groundwater of western plain (0-16.75 mg/L) are much higher compared with southern plain (0-1.5 mg/L). The groundwater in western plain is in a more reductive environment and characterized by larger molecular weight (MW) of DOM and lower polydispersity (ρ), whereas DOM with relatively small molecular weight and high polydispersity is detected in the south with a more oxidative condition. The groundwater in western plain is characterized by lower fluorescence index (f450/500) and biological index (BIX), and dominated by the high molecular weight terrestrial humic-like component and larger amounts of microbial humic-like components. Protein-like is the main component in groundwater of southern plain with higher f450/500 and BIX. The ammonium concentration in groundwater correlates well with molecular weight and increases significantly with the content of high molecular weight terrestrial humic-like component, indicating that mobilization of ammonium is more closely associated with the terrestrial organic matter of high molecular weight. This study further enriches the theory on mobilization of ammonium in Quaternary alluvial-lacustrine aquifer systems and provides theoretical basis for the local water supply security.

Contribution of groundwater discharge and associated contaminants input to Dongting Lake, Central China, using multiple tracers (222Rn, 18O, Cl-).

Lacustrine groundwater discharge (LGD) can play an important role in water and contaminant mass balance of lakes. Dongting Lake is the second largest fresh lake in China which is connected to Yangtze River and has quite prominent ecological status and function within Yangtze River basin. However, the effect of groundwater discharge on the balance of water and contaminant in Dongting Lake has long been overlooked. This study estimated the groundwater discharge and associated contaminants input into Dongting Lake during the dry season using multiple tracers (222Rn, 18O, Cl-). After sensitivity analysis of different models, it is found that the result of 222Rn mass balance model is the most reliable. Based on the 222Rn mass balance model, the groundwater discharge rate is estimated to be 73.94 mm/d and the contribution of LGD to water balance is 10.94%. As the main nutrient components, NH3-N, P and Si from groundwater input account for 23.65%, 5.12% and 30.15%  % of the total input, respectively. As the main heavy metal components, Fe, Mn and As from groundwater input all account for more than 50% of the total input. Although the LGD rate is relatively small, the contaminant input from LGD is significant enough, which may be a potential threat to the ecological stability of Dongting Lake. In this study, the mass balance models of multiple tracers were integrated to understand the role of groundwater in maintaining the water balance and pollution status of Dongting Lake, which has certain reference significance for the LGD study in plain lakes or reservoirs with complex water systems in humid regions.

Can decontamination and reuse of N95 respirators during COVID-19 pandemic provide energy, environmental, and economic benefits?

The widespread COVID-19 pandemic led to a shortage in the supply of N95 respirators in the United States until May 2021. In this study, we address the energy, environmental, and economic benefits of the decontamination-and-reuse of the N95 masks. Two popular decontamination methods, including dry heat and vapor hydrogen peroxide (VHP), are investigated in this study for their effective pathogen inactivation and favorable performance in preserving filtration efficiency and structural integrity of respirators. Two multiple reuse cases, under which the N95 masks are disinfected and used five times with the dry heat method and 20 times using the VHP method, are considered and compared with a single-use case. Compared to the single-use case, the dry heat-based multiple-use case reduces carbon footprint by 50% and cumulative energy demand (CED) by 17%, while the VHP-based case decreases carbon footprint by 67% and CED by 58%. The dry-heat-based and VHP-based multiple reuse cases also present environmental benefits in most of the other impact categories, primarily due to substituting new N95 respirators with decontaminated ones. Decontaminating and reusing respirators costs 77% and 89% less than the case of single-use and disposal. The sensitivity analysis results show that the geographical variation in the power grid and the times of respirator use are the most influential factors for carbon footprint and CED, respectively. The result also reaffirms the energy, environmental, and economic favorability of the decontamination and reuse of N95 respirators.

Enrichment of Geogenic Ammonium in Quaternary Alluvial-Lacustrine Aquifer Systems: Evidence from Carbon Isotopes and DOM Characteristics.

Geogenic ammonium in groundwater owing to mineralization of natural organic matter (NOM) has been reported in different geologic settings, but detailed mechanisms responsible for high ammonium concentration levels are poorly understood. To this end, we chose Quaternary high ammonium aquifer systems in central Yangtze River basins and used carbon isotopes in both dissolved organic carbon and inorganic carbon together with characterization of dissolved organic matter (DOM) and groundwater chemistry to reveal mechanisms related to the genesis of ammonium. The results indicate that high levels of geogenic ammonium (up to 33.50 mg/L as N) occur due to long-term water-rock interactions in a relatively sluggish hydrogeological environment with abundant organic matter that is rich in both C and N. The stable carbon isotope data suggest that ammonium in the groundwater is released from intensive degradation of organic matter with higher contents of ammonium associated with methanogenesis. The optical signatures of DOM indicate ammonium in the groundwater is mostly associated with terrestrial humic-like components rather than protein-like components. Molecular characterization of DOM by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) shows that, compared to low ammonium groundwater, high ammonium groundwater has larger mass weights, greater abundance of CHO+N compounds, higher percentages of lignin- and condensed-hydrocarbon-like components, lower H/C ratios, higher nominal oxidation state of carbon (NOSC) values and more double bonds, rings, and aromatic structures. Strong degradation of NOM and preferential utilization of energetically more favorable, terrestrial humic-like components (lignin-like as the main class) with high NOSC values facilitates the formation of high ammonium groundwater. To the best of our knowledge, this is the first effort to use carbon isotopes and DOM characteristics to identify enrichment mechanisms for geogenic ammonium in alluvial-lacustrine aquifer systems.

Effect of depositional evolution on phosphorus enrichment in aquifer sediments of alluvial-lacustrine plain.

Groundwater with high geogenic phosphorus (P) is increasingly concerned as a potential risk to surface water eutrophication. Although hydrogeochemical processes responsible for P mobilization in groundwater systems have been studied, the burial characteristics of P and the effect of depositional evolution on P enrichment in aquifer sediments remain unclear. In this study, aquifer sediments were collected from the Dongting Lake Plain (DTP) within the central Yangtze River Basin, a high P groundwater area, and the effect of depositional evolution on P enrichment was elucidated by comprehensively analyzing the lithology, grain size, geochronology, and geochemistry of the sediments, coupled with groundwater chemistry and sediment incubation experiments. The results showed that the contents of total organic carbon (TOC), iron (Fe), and P (the relative content of bioavailable phosphorus (BAP)) were higher in lacustrine sediments deposited under a warm-wet climate, but lower in fluvial sediments deposited under a cold-dry climate. During depositional evolution, the sedimentary facies mainly controlled the content of organic phosphorus (OP), while the paleo-climate controlled the content of both OP and Fe-bound inorganic P (FeP), which jointly affected total P content in aquifer sediments. Under the interaction of groundwater and sediment, the reductive dissolution of P-rich Fe (oxyhydr)oxides and the mineralization of OP in sediment continuously release P into groundwater. Notably, the rapid accumulation of alluvial sediments after the Last Glacial Maximum in the DTP and rapid evolution of Dongting Lake during the Holocene led to a large amount of organic matter (OM) and P buried in sediments, providing materials for P release in aquifers, which seriously threatens groundwater quality. This exploration can provide a new understanding of the enrichment of geogenic P in groundwater from the perspective of depositional evolution.

Coupled effects of sedimentary iron oxides and organic matter on geogenic phosphorus mobilization in alluvial-lacustrine aquifers.

The organic matter (OM) biodegradation and reductive dissolution of iron oxides have been acknowledged as key factors in the release of geogenic phosphorus (P) to groundwater. However, the coupled effects of natural OM with iron oxides on the mobilization of geogenic P remain unclear. Groundwater with high and low P concentrations has been observed in two boreholes in the alluvial-lacustrine aquifer system of the Central Yangtze River Basin. Sediment samples from these boreholes were examined for their P and Fe species as well as their OM properties. The results show that sediments from borehole S1 with high P levels contain more bioavailable P, particularly iron oxide bound P (Fe-P) and organic P (OP) than those from borehole S2 with low P levels. Regarding borehole S2, Fe-P and OP show positive correlations with total organic carbon as well as amorphous iron oxides (FeOX1), which indicate the presence of Fe-OM-P ternary complexes, further evidenced by FTIR results. In a reducing environment, the protein-like component (C3) and terrestrial humic-like component (C2) will biodegrade. In the process of C3 biodegradation, FeOX1 will act as electron acceptors and then undergo reductive dissolution. In the process of C2 biodegradation, FeOX1 and crystalline iron oxides (FeOX2) will act as electron acceptors. FeOX2 will also act as conduits in the microbial utilization pathway. However, the formation of stable P-Fe-OM ternary complexes will inhibit the reductive dissolution of iron oxides and OM biodegradation, thus inhibiting the mobilization of P. This study provides new insights into the enrichment and mobilization of P in alluvial-lacustrine aquifer systems.

Second life and recycling: Energy and environmental sustainability perspectives for high-performance lithium-ion batteries.

Second life and recycling of retired automotive lithium-ion batteries (LIBs) have drawn growing attention, as large volumes of LIBs will retire in the coming decade. Here, we illustrate how battery chemistry, use, and recycling can influence the energy and environmental sustainability of LIBs. We find that LIBs with higher specific energy show better life cycle environmental performances, but their environmental benefits from second life application are less pronounced. Direct cathode recycling is found to be the most effective in reducing life cycle environmental impacts, while hydrometallurgical recycling provides limited sustainability benefits for high-performance LIBs. Battery design with less aluminum and alternative anode materials, such as silicon-based anode, could enable more sustainable LIB recycling. Compared to directly recycling LIBs after their electric vehicle use, carbon footprint and energy use of LIBs recycled after their second life can be reduced by 8 to 17% and 2 to 6%, respectively.

Trend towards virtual and hybrid conferences may be an effective climate change mitigation strategy.

Since 2020, the COVID-19 pandemic has urged event holders to shift conferences online. Virtual and hybrid conferences are greener alternatives to in-person conferences, yet their environmental sustainability has not been fully assessed. Considering food, accommodation, preparation, execution, information and communication technology, and transportation, here we report comparative life cycle assessment results of in-person, virtual, and hybrid conferences and consider carbon footprint trade-offs between in-person participation and hybrid conferences. We find that transitioning from in-person to virtual conferencing can substantially reduce the carbon footprint by 94% and energy use by 90%. For the sake of maintaining more than 50% of in-person participation, carefully selected hubs for hybrid conferences have the potential to slash carbon footprint and energy use by two-thirds. Furthermore, switching the dietary type of future conferences to plant-based diets and improving energy efficiencies of the information and communication technology sector can further reduce the carbon footprint of virtual conferences.

Sources and enrichment of phosphorus in groundwater of the Central Yangtze River Basin.

In addition to the anthropogenic sources for elevated concentrations of phosphorus (P) in groundwater systems, the importance of geogenic enrichment of P warrants attention. To assess factors controlling the sources and enrichment processes of P in Quaternary aquifers, 355 groundwater samples were collected in the Jianghan Plain of central Yangtze River Basin. In the phreatic aquifer, the total dissolved phosphorus (TDP) concentrations range from below detection limit (BDL) to 2.56 mg/L, with 6.25% of samples exceeding 1 mg/L; in the confined aquifer, TDP concentrations range from BDL to 4.31 mg/L, with 22.18% of samples exceeding 1 mg/L. Factor analysis and correlation were used to determine major factors controlling P enrichment in the groundwater. Elevated levels of P in the confined aquifer are related to reductive dissolution of P-rich Fe(III)-(hydr)oxides (FeOOH) as well as organic phosphorus (OP) mineralization. The SEDEX sequential extraction procedure was applied to core samples from two boreholes with high and low P levels in groundwater, respectively, to characterize phosphorus speciation in aquifer sediments. Bioavailable P, particularly exchangeable P, in sediments with high P groundwater are significantly higher than those with low P groundwater. The content of Fe-bound P is higher than that of residual organic P (Res-OP) in sediments from both boreholes, indicating the greater contribution of reductive dissolution of P-rich FeOOH to geogenic P enrichment in groundwater than OP mineralization. Using the Redfield ratio, groundwater samples collected from the confined aquifer can be divided into three groups, with 65% of the samples falling into the group closely related to reduction of FeOOH. The present research provides new insights into the enrichment of geogenic P in groundwater systems, which are not only applicable in the Jianghan Plain, but also to other similar alluvial aquifers in floodplains and delta regions worldwide.

Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics.

Optogenetics has revolutionized the experimental interrogation of neural circuits and holds promise for the treatment of neurological disorders. It is limited, however, because visible light cannot penetrate deep inside brain tissue. Upconversion nanoparticles (UCNPs) absorb tissue-penetrating near-infrared (NIR) light and emit wavelength-specific visible light. Here, we demonstrate that molecularly tailored UCNPs can serve as optogenetic actuators of transcranial NIR light to stimulate deep brain neurons. Transcranial NIR UCNP-mediated optogenetics evoked dopamine release from genetically tagged neurons in the ventral tegmental area, induced brain oscillations through activation of inhibitory neurons in the medial septum, silenced seizure by inhibition of hippocampal excitatory cells, and triggered memory recall. UCNP technology will enable less-invasive optical neuronal activity manipulation with the potential for remote therapy.