Detalhe da pesquisa
1.
Elezanumab, a clinical stage human monoclonal antibody that selectively targets repulsive guidance molecule A to promote neuroregeneration and neuroprotection in neuronal injury and demyelination models.
Neurobiol Dis
; 159: 105492, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34478849
2.
Antibody-drug conjugates as targeted therapies: Are we there yet? A critical review of the current clinical landscape.
Drug Discov Today Technol
; 37: 13-22, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34895651
3.
Current Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Antibody-Drug Conjugates: An Industry White Paper.
Drug Metab Dispos
; 44(5): 617-23, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26669328
4.
Non-clinical Safety Evaluation of Biotherapeutics - Challenges, Opportunities and new Insights.
Regul Toxicol Pharmacol
; 80S: S1-S14, 2016 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-27578450
5.
Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors.
Bioorg Med Chem Lett
; 25(20): 4399-404, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26372653
6.
An IQ Consortium Perspective on Best Practices for Bioanalytical and Immunogenicity Assessment Aspects of CAR-T and TCR-T Cellular Therapies Development.
Clin Pharmacol Ther
; 115(2): 188-200, 2024 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37983584
7.
Preexisting antibody assays for gene therapy: Considerations on patient selection cutoffs and companion diagnostic requirements.
Mol Ther Methods Clin Dev
; 32(1): 101217, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38496304
8.
Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper.
Mol Ther Methods Clin Dev
; 26: 471-494, 2022 Sep 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36092368
9.
Quantitation of a recombinant monoclonal antibody in monkey serum by liquid chromatography-mass spectrometry.
Anal Biochem
; 414(1): 147-53, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21396346
10.
The Bcl-2 family antagonist ABT-737 significantly inhibits multiple animal models of autoimmunity.
J Immunol
; 182(12): 7482-9, 2009 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19494271
11.
Off-target binding of an anti-amyloid beta monoclonal antibody to platelet factor 4 causes acute and chronic toxicity in cynomolgus monkeys.
MAbs
; 13(1): 1887628, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33596779
12.
Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.
Nat Biotechnol
; 25(11): 1290-7, 2007 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17934452
13.
Synthesis and activity of N-cyanoguanidine-piperazine P2X7 antagonists.
Bioorg Med Chem Lett
; 18(14): 3848-51, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18595695
14.
Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig.
Protein Cell
; 9(1): 121-129, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28585177
15.
Citrullination: a posttranslational modification in health and disease.
Int J Biochem Cell Biol
; 38(10): 1662-77, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16730216
16.
Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-Ig(TM)) molecule that specifically and potently neutralizes both IL-1α and IL-1ß.
MAbs
; 7(3): 605-19, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25764208
17.
A high throughput capillary electrophoresis method to obtain pharmacokinetics and quality attributes of a therapeutic molecule in circulation.
MAbs
; 4(4): 521-31, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22647389
18.
Analysis of chloroquine and metabolites directly from whole-body animal tissue sections by liquid extraction surface analysis (LESA) and tandem mass spectrometry.
J Mass Spectrom
; 47(11): 1420-8, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23147817
19.
A 13C NMR approach to categorizing potential limitations of alpha,beta-unsaturated carbonyl systems in drug-like molecules.
Bioorg Med Chem Lett
; 14(22): 5503-7, 2004 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15482913