RESUMO
BACKGROUND: Statins have been shown to reduce mortality and morbidity in ischemic stroke, subarachnoid hemorrhage, and traumatic brain injuries, but their effect on intracerebral hemorrhage (ICH) remains to be determined. This study aimed to investigate the effect of prior statin use on survival following spontaneous primary intracerebral hemorrhage in a multi-ethnic Asian population. SUBJECTS AND METHODS: A study cohort of patients admitted with spontaneous primary ICH was obtained from our database. There were 1,381 patients who met the inclusion criteria. Multivariate logistic regression was used to identify independent predictors and computed odds ratios for 30-day mortality. Kaplan-Meier and Cox proportional hazard survival analyses were used to examine the effect of prior statin use on survival after ICH. RESULTS: Multivariate logistic regression controlling for baseline characteristics and in-hospital interventions, did not demonstrate any effect of prior statin use (p = 0.781) on mortality. Survival analyses also failed to demonstrate any differences in survival after ICH with prior statin use. Similarly subgroup analyses showed no difference. CONCLUSION: No beneficial effect on survival after ICH of prior statin use could be demonstrated in our large multi-ethnic Asian patient cohort.
Assuntos
Hemorragia Cerebral , Inibidores de Hidroximetilglutaril-CoA Redutases/efeitos adversos , Idoso , Povo Asiático , Hemorragia Cerebral/epidemiologia , Hemorragia Cerebral/mortalidade , Hemorragia Cerebral/prevenção & controle , Estudos de Coortes , Diversidade Cultural , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Estatísticas não Paramétricas , Análise de SobrevidaRESUMO
Ethanol is often used in sclerotherapy to treat vascular malformations. Nerve injury is a known complication of this procedure. However, the management of this complication is not well described in literature. This case describes a 10-year-old boy with a slow flow vascular malformation in the right calf who underwent transarterial ethanol embolization following prior unsuccessful direct percutaneous sclerotherapy. The development of a dense foot drop that subsequently recovered is described, and the management of this uncommon but distressful complication is discussed.