Detalhe da pesquisa
1.
Continuous glucose monitoring-derived time in range and CV are associated with altered tissue characteristics of the carotid artery wall in people with type 2 diabetes.
Diabetologia
; 66(12): 2356-2367, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37750893
2.
Discovery of a novel series of medium-sized cyclic enteropeptidase inhibitors.
Bioorg Med Chem
; 93: 117462, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37683572
3.
Associations of continuous glucose monitoring-assessed glucose variability with intima-media thickness and ultrasonic tissue characteristics of the carotid arteries: a cross-sectional analysis in patients with type 2 diabetes.
Cardiovasc Diabetol
; 20(1): 95, 2021 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33947398
4.
Plasma metabolites associated with arterial stiffness in patients with type 2 diabetes.
Cardiovasc Diabetol
; 19(1): 75, 2020 06 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32527273
5.
Discovery of benzimidazole derivatives as orally active renin inhibitors: Optimization of 3,5-disubstituted piperidine to improve pharmacokinetic profile.
Bioorg Med Chem
; 26(12): 3261-3286, 2018 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29754833
6.
Discovery of orally efficacious RORγt inverse agonists. Part 2: Design, synthesis, and biological evaluation of novel tetrahydroisoquinoline derivatives.
Bioorg Med Chem
; 26(2): 470-482, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29258712
7.
Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes.
Bioorg Med Chem
; 25(21): 5995-6006, 2017 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28988629
8.
Discovery of novel 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine derivatives as γ-secretase modulators (Part 2).
Bioorg Med Chem
; 24(14): 3192-206, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27255179
9.
Evaluation of changes in glycemic control and diabetic complications over time and factors associated with the progression of diabetic complications in Japanese patients with juvenile-onset type 1 diabetes mellitus.
J Diabetes
; 16(2): e13486, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37853936
10.
Change in fatty acid composition of plasma triglyceride caused by a 2 week comprehensive risk management for diabetes: A prospective observational study of type 2 diabetes patients with supercritical fluid chromatography/mass spectrometry-based semi-target lipidomic analysis.
J Diabetes Investig
; 14(1): 102-110, 2023 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-36208067
11.
Comparison of continuous subcutaneous insulin infusion treatment and multiple daily injection treatment on the progression of diabetic complications in Japanese patients with juvenile-onset type 1 diabetes mellitus.
J Diabetes Investig
; 13(9): 1528-1532, 2022 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-35474612
12.
Salivary metabolic signatures of carotid atherosclerosis in patients with type 2 diabetes hospitalized for treatment.
Front Mol Biosci
; 9: 1074285, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36619162
13.
Saliva and Plasma Reflect Metabolism Altered by Diabetes and Periodontitis.
Front Mol Biosci
; 8: 742002, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34589520
14.
Evaluation of change in metabolome caused by comprehensive diabetes treatment: A prospective observational study of diabetes inpatients with gas chromatography/mass spectrometry-based non-target metabolomic analysis.
J Diabetes Investig
; 12(12): 2232-2241, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34032389
15.
Plasma xanthine oxidoreductase activity in Japanese patients with type 2 diabetes across hospitalized treatment.
J Diabetes Investig
; 12(8): 1512-1520, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-33211396
16.
Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor γt (RORγt) Agonist Structure-Based Functionality Switching Approach from In House RORγt Inverse Agonist to RORγt Agonist.
J Med Chem
; 62(3): 1167-1179, 2019 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30652849
17.
Discovery of [ cis-3-({(5 R)-5-[(7-Fluoro-1,1-dimethyl-2,3-dihydro-1 H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5 H)-yl}carbonyl)cyclobutyl]acetic Acid (TAK-828F) as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist.
J Med Chem
; 61(7): 2973-2988, 2018 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29510038
18.
Highly enantioselective reformatsky reaction of ketones: chelation-assisted enantioface discrimination.
Org Lett
; 4(18): 3051-4, 2002 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12201714
19.
Design and synthesis of potent inhibitor of apoptosis (IAP) proteins antagonists bearing an octahydropyrrolo[1,2-a]pyrazine scaffold as a novel proline mimetic.
J Med Chem
; 56(3): 1228-46, 2013 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23298277