Detalhe da pesquisa
1.
Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3-(3-((5-(Azetidine-1-carbonyl)pyrazin-2-yl)oxy)-5-isopropoxybenzamido)-1H-pyrazol-1-yl)methyl)phosphonate (BMS-820132).
J Med Chem
; 65(5): 4291-4317, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35179904
2.
Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11ß-hydroxydehydrogenase 1 (11ß-HSD1).
Bioorg Med Chem Lett
; 21(22): 6693-8, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21983444
3.
Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes.
J Med Chem
; 51(5): 1145-9, 2008 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18260618
4.
Discovery of Clinical Candidate BMS-823778 as an Inhibitor of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1).
ACS Med Chem Lett
; 9(12): 1170-1174, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613321
5.
Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.
J Med Chem
; 60(12): 4932-4948, 2017 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28537398
6.
Optimization of 1,2,4-Triazolopyridines as Inhibitors of Human 11ß-Hydroxysteroid Dehydrogenase Type 1 (11ß-HSD-1).
ACS Med Chem Lett
; 5(7): 803-8, 2014 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25050169
7.
11ß-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoEâ»/â» mice.
PLoS One
; 8(2): e53192, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23383297
8.
Eleven amino acid glucagon-like peptide-1 receptor agonists with antidiabetic activity.
J Med Chem
; 52(23): 7788-99, 2009 Dec 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-19702274
9.
Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats.
Diabetes
; 57(6): 1723-9, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18356408