Detalhe da pesquisa
1.
XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer.
Proc Natl Acad Sci U S A
; 119(4)2022 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35064087
2.
Mechanism of Allosteric Modulation of Nicotinamide Phosphoribosyltransferase to Elevate Cellular NAD.
Biochemistry
; 62(4): 923-933, 2023 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36746631
3.
Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry.
PLoS Pathog
; 17(2): e1009312, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33539432
4.
Mixed lineage kinase 3 inhibition induces T cell activation and cytotoxicity.
Proc Natl Acad Sci U S A
; 117(14): 7961-7970, 2020 04 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32209667
5.
Effect of a brain-penetrant selective estrogen receptor degrader (SERD) on binge drinking in female mice.
Alcohol Clin Exp Res
; 46(7): 1313-1320, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35581531
6.
Pharmacology and Molecular Mechanisms of Clinically Relevant Estrogen Estetrol and Estrogen Mimic BMI-135 for the Treatment of Endocrine-Resistant Breast Cancer.
Mol Pharmacol
; 98(4): 364-381, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32788222
7.
Phase 1 study of TTC-352 in patients with metastatic breast cancer progressing on endocrine and CDK4/6 inhibitor therapy.
Breast Cancer Res Treat
; 183(3): 617-627, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32696319
8.
G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer.
Breast Cancer Res Treat
; 180(3): 635-646, 2020 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-32130619
9.
Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery.
Nitric Oxide
; 82: 59-74, 2019 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30394348
10.
Time-Gated Luminescence Detection of Enzymatically Produced Hydrogen Sulfide: Design, Synthesis, and Application of a Lanthanide-Based Probe.
Inorg Chem
; 57(2): 681-688, 2018 Jan 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29281273
11.
Dimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein.
J Biol Chem
; 291(7): 3639-47, 2016 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26683377
12.
Time-Gated Detection of Cystathionine γ-Lyase Activity and Inhibition with a Selective, Luminogenic Hydrogen Sulfide Sensor.
Chemistry
; 23(4): 752-756, 2017 Jan 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27734530
13.
Prodrugs Bioactivated to Quinones Target NF-κB and Multiple Protein Networks: Identification of the Quinonome.
Chem Res Toxicol
; 29(7): 1151-9, 2016 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-27258437
14.
Amyloid-ß pathology and APOE genotype modulate retinoid X receptor agonist activity in vivo.
J Biol Chem
; 289(44): 30538-30555, 2014 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-25217640
15.
Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia.
BMC Neurosci
; 16: 67, 2015 Oct 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-26480871
16.
A novel aspirin prodrug inhibits NFκB activity and breast cancer stem cell properties.
BMC Cancer
; 15: 845, 2015 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26530254
17.
Structure-Guided Design and Synthesis of Pyridinone-Based Selective Bromodomain and Extra-Terminal Domain (BET)-First Bromodomain (BD1) Inhibitors.
J Med Chem
; 67(4): 2712-2731, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38295759
18.
Channeling Nicotinamide Phosphoribosyltransferase (NAMPT) to Address Life and Death.
J Med Chem
; 67(8): 5999-6026, 2024 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-38580317
19.
Estradiol improves behavior in FAD transgenic mice that express APOE3 but not APOE4 after ovariectomy.
Front Endocrinol (Lausanne)
; 15: 1374825, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38742194
20.
Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress.
ACS Med Chem Lett
; 15(2): 205-214, 2024 Feb 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38352833