Detalhe da pesquisa
1.
A Phase II randomized controlled trial evaluated antithrombotic treatment with fesomersen in patients with kidney failure on hemodialysis.
Kidney Int
; 2024 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38537676
2.
Pharmacokinetics of rivaroxaban in children using physiologically based and population pharmacokinetic modelling: an EINSTEIN-Jr phase I study.
Thromb J
; 16: 32, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30534008
3.
Exploratory evaluation of pharmacodynamics, pharmacokinetics and safety of rivaroxaban in children and adolescents: an EINSTEIN-Jr phase I study.
Thromb J
; 16: 31, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30534007
4.
Rivaroxaban versus standard anticoagulation for acute venous thromboembolism in childhood. Design of the EINSTEIN-Jr phase III study.
Thromb J
; 16: 34, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30598642
5.
Clinical presentation and therapeutic management of venous thrombosis in young children: a retrospective analysis.
Thromb J
; 16: 29, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30410424
6.
Evaluation of changes in oral drug absorption in preterm and term neonates for Biopharmaceutics Classification System (BCS) class I and II compounds.
Br J Clin Pharmacol
; 81(1): 137-47, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26302359
7.
Pharmacokinetics, pharmacodynamics, and safety of fesomersen, a novel antisense inhibitor of factor XI, in healthy Chinese, Japanese, and Caucasian volunteers.
Clin Transl Sci
; 17(4): e13784, 2024 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38563414
8.
Model-informed bridging of rivaroxaban doses for thromboprophylaxis in pediatric patients aged 9 years and older with congenital heart disease.
CPT Pharmacometrics Syst Pharmacol
; 11(8): 1111-1121, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35665486
9.
Anticoagulation in pediatric cancer-associated venous thromboembolism: a subgroup analysis of EINSTEIN-Jr.
Blood Adv
; 6(22): 5821-5828, 2022 11 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36006613
10.
Applications of Physiologically Based Pharmacokinetic Modeling of Rivaroxaban-Renal and Hepatic Impairment and Drug-Drug Interaction Potential.
J Clin Pharmacol
; 61(5): 656-665, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33205449
11.
Population pharmacokinetic analysis of rivaroxaban in children and comparison to prospective physiologically-based pharmacokinetic predictions.
CPT Pharmacometrics Syst Pharmacol
; 10(10): 1195-1207, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34292671
12.
Rivaroxaban for treatment of pediatric venous thromboembolism. An Einstein-Jr phase 3 dose-exposure-response evaluation.
J Thromb Haemost
; 18(7): 1672-1685, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32246743
13.
Rivaroxaban compared with standard anticoagulants for the treatment of acute venous thromboembolism in children: a randomised, controlled, phase 3 trial.
Lancet Haematol
; 7(1): e18-e27, 2020 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-31699660
14.
Cytochrome P450-mediated metabolism in the human gut wall.
J Pharm Pharmacol
; 61(5): 541-58, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19405992
15.
Whole-body physiologically based pharmacokinetic population modelling of oral drug administration: inter-individual variability of cimetidine absorption.
J Pharm Pharmacol
; 61(7): 891-9, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19589231
16.
BAY 1213790, a fully human IgG1 antibody targeting coagulation factor XIa: First evaluation of safety, pharmacodynamics, and pharmacokinetics.
Res Pract Thromb Haemost
; 3(2): 242-253, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-31011708
17.
Bodyweight-adjusted rivaroxaban for children with venous thromboembolism (EINSTEIN-Jr): results from three multicentre, single-arm, phase 2 studies.
Lancet Haematol
; 6(10): e500-e509, 2019 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-31420317
18.
Towards quantitative prediction of oral drug absorption.
Clin Pharmacokinet
; 47(10): 655-67, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18783296
19.
Development of a Whole-Body Physiologically Based Pharmacokinetic Approach to Assess the Pharmacokinetics of Drugs in Elderly Individuals.
Clin Pharmacokinet
; 55(12): 1573-1589, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27351180
20.
Development of a Physiologically-Based Pharmacokinetic Model for Preterm Neonates: Evaluation with In Vivo Data.
Curr Pharm Des
; 21(39): 5688-98, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26323410