Detalhe da pesquisa
1.
SARS-CoV-2 tropism, entry, replication, and propagation: Considerations for drug discovery and development.
PLoS Pathog
; 17(2): e1009225, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33596266
2.
Discovery of NXT-10796, an orally active, intestinally restricted EP4 agonist prodrug for the treatment of inflammatory bowel disease.
Bioorg Med Chem Lett
; 91: 129351, 2023 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37270073
3.
Functional defects in Clostridium difficile TcdB toxin uptake identify CSPG4 receptor-binding determinants.
J Biol Chem
; 292(42): 17290-17301, 2017 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28842504
4.
Disease Progression and Resolution in Rodent Models of Clostridium difficile Infection and Impact of Antitoxin Antibodies and Vancomycin.
Antimicrob Agents Chemother
; 60(11): 6471-6482, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27527088
5.
Mechanism of action and epitopes of Clostridium difficile toxin B-neutralizing antibody bezlotoxumab revealed by X-ray crystallography.
J Biol Chem
; 289(26): 18008-21, 2014 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24821719
6.
Mechanisms of protection against Clostridium difficile infection by the monoclonal antitoxin antibodies actoxumab and bezlotoxumab.
Infect Immun
; 83(2): 822-31, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25486992
7.
Broad coverage of genetically diverse strains of Clostridium difficile by actoxumab and bezlotoxumab predicted by in vitro neutralization and epitope modeling.
Antimicrob Agents Chemother
; 59(2): 1052-60, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25451052
8.
Structure Guided Discovery of Novel Pan Metallo-ß-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
J Med Chem
; 67(5): 3400-3418, 2024 Mar 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38387069
9.
Distinct subsets of neutrophils crosstalk with cytokines and metabolites in patients with sepsis.
iScience
; 26(2): 105948, 2023 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36756375
10.
A high-throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell-based assays.
Bioeng Transl Med
; 8(5): e10542, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-37693049
11.
Broadening the spectrum of ß-lactam antibiotics through inhibition of signal peptidase type I.
Antimicrob Agents Chemother
; 56(9): 4662-70, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22710113
12.
Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated gene.
Respir Res
; 13: 92, 2012 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23061798
13.
The impact of DAMP-mediated inflammation in severe COVID-19 and related disorders.
Biochem Pharmacol
; 195: 114847, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34801526
14.
Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
J Med Chem
; 65(24): 16234-16251, 2022 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36475645
15.
The identification of substituted benzothiophene derivatives as PGE(2) subtype 4 receptor antagonists: From acid to non-acid.
Bioorg Med Chem Lett
; 21(2): 734-7, 2011 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21208803
16.
Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.
Bioorg Med Chem Lett
; 21(3): 1041-6, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21215624
17.
Immunomodulation by the Commensal Microbiome During Immune-Targeted Interventions: Focus on Cancer Immune Checkpoint Inhibitor Therapy and Vaccination.
Front Immunol
; 12: 643255, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34054810
18.
Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.
Bioorg Med Chem Lett
; 20(12): 3760-3, 2010 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20471829
19.
Adenovirus IL-13-induced airway disease in mice: a corticosteroid-resistant model of severe asthma.
Am J Respir Cell Mol Biol
; 39(1): 26-35, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18258919
20.
MF498 [N-{[4-(5,9-Diethoxy-6-oxo-6,8-dihydro-7H-pyrrolo[3,4-g]quinolin-7-yl)-3-methylbenzyl]sulfonyl}-2-(2-methoxyphenyl)acetamide], a selective E prostanoid receptor 4 antagonist, relieves joint inflammation and pain in rodent models of rheumatoid and osteoarthritis.
J Pharmacol Exp Ther
; 325(2): 425-34, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18287210