Detalhe da pesquisa
1.
XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer.
Proc Natl Acad Sci U S A
; 119(4)2022 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35064087
2.
Abietic acid attenuates RANKL induced osteoclastogenesis and inflammation associated osteolysis by inhibiting the NF-KB and MAPK signaling.
J Cell Physiol
; 234(1): 443-453, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29932225
3.
Synthesis of some novel orcinol based coumarin triazole hybrids with capabilities to inhibit RANKL-induced osteoclastogenesis through NF-κB signaling pathway.
Bioorg Chem
; 78: 94-102, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29550534
4.
Design and synthesis of 4'-O-alkylamino-tethered-benzylideneindolin-2-ones as potent cytotoxic and apoptosis inducing agents.
Bioorg Med Chem Lett
; 26(16): 4061-9, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27397498
5.
Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK Signalling.
Pharmacol Res
; 99: 63-73, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26022736
6.
Design and synthesis of dithiocarbamate linked ß-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability.
Bioorg Med Chem
; 23(17): 5511-26, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26264845
7.
Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells.
Apoptosis
; 19(7): 1148-64, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24729100
8.
Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice.
Cell Death Discov
; 9(1): 1, 2023 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36588105
9.
BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers.
J Hematol Oncol
; 15(1): 23, 2022 03 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35260176
10.
Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL-Specific Degrader DT2216.
Mol Cancer Ther
; 21(1): 184-192, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34667112
11.
Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition.
J Med Chem
; 64(19): 14230-14246, 2021 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34533954
12.
Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.
Nat Commun
; 12(1): 6896, 2021 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34824248
13.
Local administration of 4-Thiouridine, a novel molecule with potent anti-inflammatory properties, protects against experimental colitis and arthritis.
Int Immunopharmacol
; 85: 106598, 2020 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-32442901
14.
Discovery of PROTAC BCL-XL degraders as potent anticancer agents with low on-target platelet toxicity.
Eur J Med Chem
; 192: 112186, 2020 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32145645
15.
Discovery of IAP-recruiting BCL-XL PROTACs as potent degraders across multiple cancer cell lines.
Eur J Med Chem
; 199: 112397, 2020 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32388279
16.
DT2216-a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas.
J Hematol Oncol
; 13(1): 95, 2020 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32677976
17.
Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy.
Cancer Res
; 80(15): 3101-3115, 2020 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32238357
18.
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.
Nat Commun
; 11(1): 1996, 2020 04 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32332723
19.
Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-XL.
Chem Commun (Camb)
; 55(98): 14765-14768, 2019 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31754664
20.
Cellular senescence and radiation-induced pulmonary fibrosis.
Transl Res
; 209: 14-21, 2019 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30981698