Detalhe da pesquisa
1.
Stereodivergent Synthesis of Biologically Active Spironucleoside Scaffolds via Catalytic Cyclopropanation of 4-exo-Methylene Furanosides.
J Org Chem
; 86(23): 17344-17361, 2021 12 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34748342
2.
Synthesis and Reactivity of Spirocarbocycles as Scaffolds for Nucleoside Analogues.
J Org Chem
; 85(23): 14989-15005, 2020 12 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33196210
3.
Preparation of 4'-Spirocyclobutyl Nucleoside Analogues as Novel and Versatile Adenosine Scaffolds.
Chemistry
; 25(67): 15419-15423, 2019 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31609050
4.
Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application.
Bioorg Med Chem Lett
; 23(1): 310-7, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23177258
5.
Characterization of 2-[[4-fluoro-3-(trifluoromethyl)phenyl]amino]-4-(4-pyridinyl)-5-thiazolemethanol (JNJ-1930942), a novel positive allosteric modulator of the {alpha}7 nicotinic acetylcholine receptor.
J Pharmacol Exp Ther
; 336(2): 560-74, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21084390
6.
Synthesis of 3-amino-4-fluoropyrazoles.
J Org Chem
; 76(10): 4105-11, 2011 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21500813
7.
Regio- and Stereoselective Synthesis of C-4' Spirocyclobutyl Ribofuranose Scaffolds and Their Use as Biologically Active Nucleoside Analogues.
Org Lett
; 23(22): 8828-8833, 2021 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34730365
8.
Discovery and Pharmacological Characterization of JNJ-64619178, a Novel Small-Molecule Inhibitor of PRMT5 with Potent Antitumor Activity.
Mol Cancer Ther
; 20(12): 2317-2328, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34583982
9.
Synthesis of 4-substituted 3,3-difluoropiperidines.
J Org Chem
; 75(3): 929-32, 2010 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20050617
10.
Synthesis of 5-amino- and 5-hydroxy-3,3-difluoropiperidines.
Org Biomol Chem
; 8(20): 4514-7, 2010 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20668779
11.
Synthesis of aminomethylated 4-fluoropiperidines and 3-fluoropyrrolidines.
Org Biomol Chem
; 8(11): 2509-12, 2010 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20407687
12.
A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode.
ACS Med Chem Lett
; 11(11): 2227-2231, 2020 Nov 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33214833
13.
New synthesis of 3-fluoropyrroles.
J Org Chem
; 74(3): 1377-80, 2009 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-19115927
14.
Synthesis of 1-Boc-3-fluoroazetidine-3-carboxylic acid.
J Org Chem
; 74(5): 2250-3, 2009 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-19216497
15.
New entries toward 3,3-difluoropiperidines.
J Org Chem
; 73(14): 5458-61, 2008 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-18547110
16.
Correction to "Regio- and Stereoselective Synthesis of C-4' Spirocyclobutyl Ribofuranose Scaffolds and Their Use as Biologically Active Nucleoside Analogues".
Org Lett
; 24(2): 798, 2022 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34978448
17.
Enzymatic Kinetic Resolution of 5-Hydroxy-4-oxa-endo-tricyclo[5.2.1.0(2,6)]dec-8-en-3-ones: A Useful Approach to D-Ring Synthons for Strigol Analogues with Remarkable Stereoselectivity.
J Org Chem
; 61(20): 6931-6935, 1996 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-11667588
18.
Comparative study of the active site caging of serine proteases: thrombin and factor Xa.
Biochemistry
; 41(6): 2002-13, 2002 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-11827547