Association between sleep disorders and constipation Risk: A systematic review and Meta-Analysis.

OBJECTIVES: The objective of this study was to evaluate the potential relationship between sleep disturbances and various types of constipation in patients. METHODS: We conducted systematic searches in the research databases PubMed, EMBASE, Web of Science, and Cochrane Library to identify qualifying studies. Using Stata software version 14.0, we calculated the Odds Ratio (OR) and 95 % confidence interval (CI) for constipation in patients with sleep disorders. If P > 0.1 and I2 ≤ 50 %, we employed a fixed-effects model; otherwise, we applied a random-effects model. We assessed publication bias using funnel plots and Egger's test. RESULT: The pooled analysis demonstrated that individuals with sleep disorders were associated with an increased risk of all-cause constipation (OR = 1.47; 95 %CI: 1.31-1.64; I2 = 88.8 %, P＜0.001). Specifically, both children (OR = 1.29; 95 %CI: 1.16-1.42; I2 = 63.8 %, P＜0.001) and adults (OR = 1.65; 95 %CI: 1.39-1.97; I2 = 92.4 %, P＜0.001) with a history of sleep disorders exhibited an increased risk of all-cause constipation.. Furthermore, patients with a history of insufficient sleep were also associated with an increased risk of constipation (OR = 1.33; 95 %CI: 1.20-1.46; I2 = 6.7 %, P＜0.001). Additionally, patients with poor sleep quality were found to have an increased risk of constipation (OR = 1.56; 95 %CI: 1.0-2.45; I2 = 90.9 %, P = 0.05). Lastly, patients with insomnia were found to have the highest risk of constipation (OR = 1.94; 95 %CI: 1.37-2.76; I2 = 97.8 %, P＜0.001). CONCLUSION: This meta-analysis indicates that sleep disorders are associated with an elevated risk of constipation. Insomnia, poor sleep quality, and insufficient sleep duration all contribute to elevating the risk of constipation. These findings emphasize the significance of recognizing sleep disorders as an independent risk factor for constipation in both children and adults.

Design and Analysis of a Pneumatic Spring Testing System for Precision Manufacturing.

The vibration isolation effect of the pneumatic spring determines the precision of the manufacturing. In this paper, in order to detect the performance of a pneumatic spring, a multi frequency band testing system with different payload is designed and developed. First, the pneumatic spring structure is analyzed, and the stiffness of the pneumatic spring is obtained based on the ideal gas model, Kelvin-Voigt model, and finite element method. Then, to verify the reliability of the system, a dynamic model of the vibration platform is established. Through an analysis of the simulation using the Simulink environment, critical parameters are determined, and the effective conditions of the vibration isolation are obtained. Based on the results from the simulation and experiment, the transmission rate is around 20% under 40 Hz vibration, and 12% under 100 Hz vibration. The pneumatic spring proves to be effective under vibrations beyond 7 H. This achievement will become an important basis for future research concerning precision manufacturing.

A novel inhibition mechanism of aniline on nitrification: Aniline degradation competes dissolved oxygen with nitrification.

Aniline is a toxic aromatic amine and an inhibitor of nitrification. This study explored the inhibition effect and underlying mechanism. After sludge acclimation, 540 mg/L aniline was removed in 24 h and almost all ammonia released from aniline was oxidized to nitrate. However, nitrification never started until no aniline left. The cellular adenosine triphosphate (cATP) concentration of acclimated sludge reduced only by 2% after aniline exposure. Neither transmembrane transport of ammonia nor ammonia monooxygenase (AMO) activity was affected by aniline. Growing initial aniline concentration did not deteriorate the specific nitrification rate (NR). These all revealed that the toxicity of aniline only play a minor role in inhibition. Competition for dissolved oxygen (DO) was proposed to be another possible inhibition mechanism. The oxygen affinity constant (Ks) of aniline degraders and ammonia-oxidizing bacteria (AOB) was calculated to be 0.894 mg/L and 1.274 mg/L respectively, suggesting the former possessed much stronger oxygen affinity (P < 0.01). With aniline and ammonium as initial substrates, increasing aeration intensity advanced nitrification and increased the NR. Max NR of 0.63 mgN/(gMLSS·h) was achieved at the highest aeration intensity of 1000 mL/min. This study brings one step closer to better removal of aniline and derived nitrogen pollutants.