Detalhe da pesquisa
1.
Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxysterol, 25-hydroxycholesterol.
J Lipid Res
; 64(4): 100350, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36849076
2.
Quantifying dynamic range in red blood cell energetics: Evidence of progressive energy failure during storage.
Transfusion
; 61(5): 1586-1599, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33830505
3.
Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.
Bioorg Med Chem
; 28(1): 115194, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31786008
4.
Effect of plasma processing and storage on microparticle abundance, nitric oxide scavenging, and vasoactivity.
Transfusion
; 59(S2): 1568-1577, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30980740
5.
Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Eur Biophys J
; 47(3): 271-290, 2018 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28975383
6.
Thiazole-substituted benzenesulfonamides as inhibitors of 12 human carbonic anhydrases.
Bioorg Chem
; 77: 534-541, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29459130
7.
The potent BACE1 inhibitor LY2886721 elicits robust central Aß pharmacodynamic responses in mice, dogs, and humans.
J Neurosci
; 35(3): 1199-210, 2015 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25609634
8.
Preparation and biological evaluation of conformationally constrained BACE1 inhibitors.
Bioorg Med Chem
; 23(13): 3260-8, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26001341
9.
ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments.
Appl Magn Reson
; 46(8): 853-873, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26224994
10.
4-Substituted-2,3,5,6-tetrafluorobenzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, XII, and XIII.
Bioorg Med Chem
; 21(7): 2093-106, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23394791
11.
Robust central reduction of amyloid-ß in humans with an orally available, non-peptidic ß-secretase inhibitor.
J Neurosci
; 31(46): 16507-16, 2011 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22090477
12.
Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation.
Mol Pharmacol
; 80(2): 267-80, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21543522
13.
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
J Med Chem
; 64(15): 11148-11168, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34342224
14.
Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor.
J Med Chem
; 64(12): 8076-8100, 2021 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34081466
15.
A pilot study on the kinetics of metabolites and microvascular cutaneous effects of nitric oxide inhalation in healthy volunteers.
PLoS One
; 14(8): e0221777, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31469867
16.
Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics.
Biochem J
; 402(2): 251-60, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17064256
17.
Cryo-electron microscopy structure of a human PRMT5:MEP50 complex.
PLoS One
; 13(3): e0193205, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29518110
18.
Red blood cell phenotype fidelity following glycerol cryopreservation optimized for research purposes.
PLoS One
; 13(12): e0209201, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30576340
19.
Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors.
Oncotarget
; 9(17): 13796-13806, 2018 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29568395
20.
Intrinsic Thermodynamics and Structures of 2,4- and 3,4-Substituted Fluorinated Benzenesulfonamides Binding to Carbonic Anhydrases.
ChemMedChem
; 12(2): 161-176, 2017 01 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28001003