Detalhe da pesquisa
1.
Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints.
Bioorg Med Chem
; 28(1): 115194, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31786008
2.
The potent BACE1 inhibitor LY2886721 elicits robust central Aß pharmacodynamic responses in mice, dogs, and humans.
J Neurosci
; 35(3): 1199-210, 2015 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25609634
3.
Preparation and biological evaluation of conformationally constrained BACE1 inhibitors.
Bioorg Med Chem
; 23(13): 3260-8, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26001341
4.
ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments.
Appl Magn Reson
; 46(8): 853-873, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26224994
5.
Robust central reduction of amyloid-ß in humans with an orally available, non-peptidic ß-secretase inhibitor.
J Neurosci
; 31(46): 16507-16, 2011 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22090477
6.
Structural and functional analysis of two new positive allosteric modulators of GluA2 desensitization and deactivation.
Mol Pharmacol
; 80(2): 267-80, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21543522
7.
Discovery of a First-in-Class Inhibitor of the PRMT5-Substrate Adaptor Interaction.
J Med Chem
; 64(15): 11148-11168, 2021 08 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34342224
8.
Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor.
J Med Chem
; 64(12): 8076-8100, 2021 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34081466
9.
Slow-onset inhibition of fumarylacetoacetate hydrolase by phosphinate mimics of the tetrahedral intermediate: kinetics, crystal structure and pharmacokinetics.
Biochem J
; 402(2): 251-60, 2007 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17064256
10.
Cryo-electron microscopy structure of a human PRMT5:MEP50 complex.
PLoS One
; 13(3): e0193205, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29518110
11.
Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors.
Oncotarget
; 9(17): 13796-13806, 2018 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29568395
12.
Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages.
PLoS One
; 12(4): e0175758, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28406969
13.
The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines.
Mol Cancer Ther
; 3(1): 1-9, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-14749470
14.
Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site.
Bioorg Med Chem Lett
; 17(6): 1765-8, 2007 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17239592
15.
Pyrithiamine as a substrate for thiamine pyrophosphokinase.
J Biol Chem
; 281(10): 6601-7, 2006 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16365036
16.
Aminoimidazo[1,2-a]pyridines as a new structural class of cyclin-dependent kinase inhibitors. Part 1: Design, synthesis, and biological evaluation.
Bioorg Med Chem Lett
; 14(24): 6095-9, 2004 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-15546737