Association between wrist ratio and carpal tunnel syndrome: Effect modification by body mass index.

INTRODUCTION: Previous studies have reported higher wrist ratios (WR) related to carpal tunnel syndrome (CTS) but have not assessed effect modification by obesity and may have inadequately controlled for confounders. METHODS: Baseline data of a multicenter prospective cohort study were analyzed. CTS was defined by nerve conduction study (NCS) criteria and symptoms. RESULTS: Among the 1,206 participants, a square-shaped wrist was associated with CTS after controlling for confounders (prevalence ratio = 2.27; 95% confidence interval [95% CI], 1.33-3.86). Body mass index (BMI) was a strong effect modifier on the relationship between WR and both CTS and abnormal NCS results, with normal weight strata of rectangular versus square wrists = 8.18 (95% CI, 1.63-49.96) and 7.12 (95% CI, 2.19-23.16), respectively. DISCUSSION: A square wrist is significantly associated with CTS after controlling for confounders. Effect modification by high BMI masked the eightfold magnitude adjusted relationship seen between WR and CTS among normal weight participants. Muscle Nerve 56: 1047-1053, 2017.

Association between lifting and use of medication for low back pain: results from the Backworks Prospective Cohort Study.

OBJECTIVE: To evaluate relationships between lifting and lowering of loads and risk of low back pain resulting in medication use (M-LBP). METHODS: At baseline, worker demographics, psychosocial factors, hobbies, LBP history, and lifting and lowering (quantified using the Revised NIOSH Lifting Equation) were assessed. A cohort of 258 incident-eligible workers was followed up for 4.5 years to determine new M-LBP cases and changes in lifting/lowering requirements. Proportional hazards regression with time-varying covariates was used to model associations. RESULTS: Factors predicting M-LBP included peak lifting index (PLI) and composite lifting index (PCLI), LBP history, anxiety, and housework. In adjusted models, PLI and PCLI showed exposure-response relationships with peak hazard ratios of 3.8 and 4.3, respectively (P ≤ 0.02). CONCLUSIONS: Lifting of loads is associated with increased risk of M-LBP. The PLI and PCLI are useful metrics for estimating the risk of M-LBP from lifting.