Detalhe da pesquisa
1.
Large-Scale Virtual Screening for the Discovery of SARS-CoV-2 Papain-like Protease (PLpro) Non-covalent Inhibitors.
J Chem Inf Model
; 63(7): 2158-2169, 2023 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36930801
2.
Development of VPC-70619, a Small-Molecule N-Myc Inhibitor as a Potential Therapy for Neuroendocrine Prostate Cancer.
Int J Mol Sci
; 23(5)2022 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-35269731
3.
A functional substitution in the L-aromatic amino acid decarboxylase enzyme worsens somatic symptoms via a serotonergic pathway.
Ann Neurol
; 86(2): 168-180, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31177555
4.
Dual-Inhibitors of N-Myc and AURKA as Potential Therapy for Neuroendocrine Prostate Cancer.
Int J Mol Sci
; 21(21)2020 Nov 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33167327
5.
Molecular basis of interactions between SH3 domain-containing proteins and the proline-rich region of the ubiquitin ligase Itch.
J Biol Chem
; 292(15): 6325-6338, 2017 04 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28235806
6.
A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect
; 12(2): 2246594, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37555275
7.
Targeting SARS-CoV-2 papain-like protease in the postvaccine era.
Trends Pharmacol Sci
; 43(11): 906-919, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36114026
8.
Artificial intelligence-enabled virtual screening of ultra-large chemical libraries with deep docking.
Nat Protoc
; 17(3): 672-697, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35121854
9.
X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation.
Nat Commun
; 13(1): 5196, 2022 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36057636
10.
Drugging the 'undruggable'. Therapeutic targeting of protein-DNA interactions with the use of computer-aided drug discovery methods.
Drug Discov Today
; 26(11): 2660-2679, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34332092
11.
Automated discovery of noncovalent inhibitors of SARS-CoV-2 main protease by consensus Deep Docking of 40 billion small molecules.
Chem Sci
; 12(48): 15960-15974, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35024120
12.
Rapid Identification of Potential Inhibitors of SARS-CoV-2 Main Protease by Deep Docking of 1.3â Billion Compounds.
Mol Inform
; 39(8): e2000028, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32162456
13.
Deep Docking: A Deep Learning Platform for Augmentation of Structure Based Drug Discovery.
ACS Cent Sci
; 6(6): 939-949, 2020 Jun 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32607441
14.
Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site.
Nat Commun
; 11(1): 5877, 2020 11 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33208735