Detalhe da pesquisa
1.
Programming inactive RNA-binding small molecules into bioactive degraders.
Nature
; 618(7963): 169-179, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37225982
2.
Decreasing the intrinsically disordered protein α-synuclein levels by targeting its structured mRNA with a ribonuclease-targeting chimera.
Proc Natl Acad Sci U S A
; 121(2): e2306682120, 2024 Jan 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38181056
3.
DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor.
Proc Natl Acad Sci U S A
; 119(6)2022 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35110406
4.
A blood-brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome.
Proc Natl Acad Sci U S A
; 119(48): e2210532119, 2022 11 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36409902
5.
Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA.
J Am Chem Soc
; 144(26): 11620-11625, 2022 07 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35737519
6.
Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment.
J Am Chem Soc
; 143(33): 13044-13055, 2021 08 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-34387474
7.
Small molecule recognition of disease-relevant RNA structures.
Chem Soc Rev
; 49(19): 7167-7199, 2020 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32975549
8.
Correction to "Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA".
J Am Chem Soc
; 145(16): 9364, 2023 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37058601
9.
Heterobifunctional small molecules to modulate RNA function.
Trends Pharmacol Sci
; 45(5): 449-463, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38641489
10.
Altering the Cleaving Effector in Chimeric Molecules that Target RNA Enhances Cellular Selectivity.
ACS Chem Biol
; 18(11): 2385-2393, 2023 11 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37824291
11.
Methods for the study of ribonuclease targeting chimeras (RiboTACs).
Methods Enzymol
; 692: 249-298, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37925183
12.
Transcriptome-Wide Studies of RNA-Targeted Small Molecules Provide a Simple and Selective r(CUG)exp Degrader in Myotonic Dystrophy.
ACS Cent Sci
; 9(7): 1342-1353, 2023 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37521782
13.
Bioinformatic Searching for Optimal RNA Targets of Dimeric Compounds Informs Design of a MicroRNA-27a Inhibitor.
ACS Chem Biol
; 17(1): 5-10, 2022 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34898169
14.
Targeting RNA structures with small molecules.
Nat Rev Drug Discov
; 21(10): 736-762, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35941229
15.
A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype.
Cell Chem Biol
; 29(2): 300-311.e10, 2022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34320373
16.
Systematically Studying the Effect of Small Molecules Interacting with RNA in Cellular and Preclinical Models.
ACS Chem Biol
; 16(7): 1111-1127, 2021 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34166593
17.
Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G4C2) repeat expansion in vitro and in vivo ALS models.
Sci Transl Med
; 13(617): eabd5991, 2021 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-34705518
18.
Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders.
ACS Cent Sci
; 6(10): 1713-1721, 2020 Oct 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33140033