Impairment of antioxidant enzymes, lipid peroxidation and 8-oxo-2'-deoxyguanosine in advanced epithelial ovarian carcinoma of a Spanish community.

In the present study, we describe the changes of antioxidant enzyme activities and other oxidative stress-related parameters in a mediterranean cohort of women affected with epithelial ovarian carcinoma (EOC). For that purpose, the most representative enzymatic activities, such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) and the oxidized/reduced glutathione (GSSG/GSH) ratio have been analyzed in tumor tissue biopsies and compared with the normal tissue of the same patient. As oxidation products, the levels of malondialdehyde (MDA) as an indication of lipid peroxidation, and the DNA damaged base 8-oxo-2'-deoxyguanosine (8-oxo-dG) have been also measured. Advanced EOC show reduced levels of SOD and CAT, while that of GPx is increased when compared with non-neoplastic tissue. The levels of GSH are increased giving as a result a reduction of the oxidative stress marker GSSG/GSH ratio comparing normal ovarian tissue with tumor tissue. In addition, the oxidation products MDA and 8-oxo-dG are significantly increased in tumor tissue, suggesting a shift of oxidative metabolisms towards a pro-oxidation state and potential gene instability in malignant ovary cells. The possible implication of the redox changes and DNA damage in tumor development is discussed.

Malestar depresivo en jóvenes universitarios: impacto de un modelo de psicoterapia breve focalizada con orientación psicoanalítica / Depressive symptomatology in young university students: Impact of a brief psychotherapy model focused with psychoanalytic orientation

El estudio tiene como objetivo evaluar los efectos de una psicoterapia breve focal psicoanalíticamente orientada en una muestra de 38 jóvenes universitarios con sintomatología depresiva leve o moderada y malestar emocional general de una Facultad de la UNAM. Se utilizó un diseño cuasiexperimental pretest-postest y seguimientos. Se utilizaron los instrumentos Inventario de Depresión de Beck (BDI), Escala de Malestar Psicológico de Kessler (K-10), Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM), y se recolectaron datos sociodemográficos, escolares y clínicos de los participantes. Los resultados de Wilcoxon y Friedman confirman mejoras estadísticamente significativas en la sintomatología. Según los resultados de Q de Cochran, también hubo mejoras en la sensación de malestar en los participantes. Concluimos que los resultados son alentadores en cuanto a la modalidad de la psicoterapia realizada, respecto a su utilidad y relevancia clínica en el trabajo con jóvenes universitarios

The study aims to assess the effects of a psychoanalytically oriented brief psychotherapy in a sample of 38 university students with mild or moderate depressive symptoms and general emotional distress at a UNAM School. A quasi-experimental pretest-posttest design and follow-ups were used. Beck Depression Inventory (BDI), Kessler Psychological Discomfort Scale (K-10), Clinical Outcomes in Routine Evaluation-Outcome Measure (CORE-OM) were used, and sociodemographic, school and clinical data were collected from the participants. The results of Wilcoxon and Friedman confirm statistically significant improvements in the symptomatology. According to the results of Q de Cochran, there were also improvements in the feeling of discomfort in the participants. We conclude that the results are encouraging in terms of the modality of psychotherapy performed, regarding its usefulness and clinical relevance in working with university students