1.
Org Biomol Chem
; 15(30): 6302-6305, 2017 Aug 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28678242
RESUMO
We developed a novel methodology using cyclic α,α-disubstituted α-amino acids (dAAs) with an acetal-side chain to control peptide secondary structures. The introduction of cyclic dAAs into peptides contributed to the stabilization of peptide secondary structures as a helix, while an acidic treatment of peptides resulted in a marked conformational change.