1.
Bioorg Med Chem Lett
; 23(24): 6933-7, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24176395
RESUMO
A series of 2-(2-phenylmorpholin-4-yl)pyrimidin-4(3H)-ones was synthesized and examined for their inhibitory activity against glycogen synthase kinase-3ß (GSK-3ß). We found 21, 29 and 30 to possess potent in vitro GSK-3ß inhibitory activity with good in vitro PK profiles. 21 demonstrated significant decrease of tau phosphorylation after oral administration in mice and excellent PK profiles.