Detalhe da pesquisa
1.
Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups.
Bioorg Med Chem Lett
; 92: 129394, 2023 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37379958
2.
TorsionNet: A Deep Neural Network to Rapidly Predict Small-Molecule Torsional Energy Profiles with the Accuracy of Quantum Mechanics.
J Chem Inf Model
; 62(4): 785-800, 2022 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35119861
3.
Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease.
J Lipid Res
; 61(8): 1192-1202, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32482718
4.
Generative Network Complex for the Automated Generation of Drug-like Molecules.
J Chem Inf Model
; 60(12): 5682-5698, 2020 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32686938
5.
Are 2D fingerprints still valuable for drug discovery?
Phys Chem Chem Phys
; 22(16): 8373-8390, 2020 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32266895
6.
Comprehensive Assessment of Torsional Strain in Crystal Structures of Small Molecules and Protein-Ligand Complexes using ab Initio Calculations.
J Chem Inf Model
; 59(10): 4195-4208, 2019 10 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31573196
7.
Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell-Type-Specific Gene Editing.
J Am Chem Soc
; 140(21): 6596-6603, 2018 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-29668265
8.
Induction of human cytochrome P450 3A4 by the irreversible myeloperoxidase inactivator PF-06282999 is mediated by the pregnane X receptor.
Xenobiotica
; 48(7): 647-655, 2018 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28685622
9.
Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.
J Am Chem Soc
; 139(9): 3528-3536, 2017 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28230359
10.
Development of a selective activity-based probe for glycosylated LIPA.
Bioorg Med Chem Lett
; 26(8): 1993-6, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26965858
11.
Expression and functional characterization of human lysosomal acid lipase gene (LIPA) mutation responsible for cholesteryl ester storage disease (CESD) phenotype.
Protein Expr Purif
; 110: 22-9, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25620107
12.
Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg Med Chem Lett
; 25(22): 5352-6, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26411795
13.
Toward a unified model of passive drug permeation II: the physiochemical determinants of unbound tissue distribution with applications to the design of hepatoselective glucokinase activators.
Drug Metab Dispos
; 42(10): 1599-610, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25024402
14.
Identification of a novel conformationally constrained glucagon receptor antagonist.
Bioorg Med Chem Lett
; 24(3): 839-44, 2014 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24418771
15.
The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 23(10): 3051-8, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23562063
16.
Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.
Bioorg Med Chem Lett
; 23(16): 4571-8, 2013 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23831135
17.
Identification of potent, selective, CNS-targeted inverse agonists of the ghrelin receptor.
Bioorg Med Chem Lett
; 23(19): 5410-4, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23953189
18.
Structure-guided inhibitor design for human acetyl-coenzyme A carboxylase by interspecies active site conversion.
J Biol Chem
; 286(48): 41510-41519, 2011 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21953464
19.
A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity.
Bioorg Med Chem Lett
; 22(1): 415-20, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22119466
20.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 22(23): 7100-5, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23089526