Detalhe da pesquisa
1.
Small-molecule-induced epigenetic rejuvenation promotes SREBP condensation and overcomes barriers to CNS myelin regeneration.
Cell
; 187(10): 2465-2484.e22, 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38701782
2.
TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS.
Cell
; 183(3): 636-649.e18, 2020 10 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-33031745
3.
Sex-Dependent Changes to the Intestinal and Hepatic Abundance of Drug Transporters and Metabolizing Enzymes in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis.
Mol Pharm
; 21(4): 1756-1767, 2024 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38415587
4.
Sphingolipids metabolism alteration in the central nervous system: Amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases.
Semin Cell Dev Biol
; 112: 82-91, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33160824
5.
The Amyotrophic Lateral Sclerosis M114T PFN1 Mutation Deregulates Alternative Autophagy Pathways and Mitochondrial Homeostasis.
Int J Mol Sci
; 23(10)2022 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35628504
6.
Stimulation of mTOR-independent autophagy and mitophagy by rilmenidine exacerbates the phenotype of transgenic TDP-43 mice.
Neurobiol Dis
; 154: 105359, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33798740
7.
Exploring germline recombination in Nestin-Cre transgenic mice using floxed androgen receptor.
Genesis
; 58(10-11): e23390, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32744751
8.
Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS.
Neurochem Res
; 45(6): 1451-1459, 2020 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-32410044
9.
The P2X7 receptor antagonist JNJ-47965567 administered thrice weekly from disease onset does not alter progression of amyotrophic lateral sclerosis in SOD1G93A mice.
Purinergic Signal
; 16(1): 109-122, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32170537
10.
TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway.
Hum Mol Genet
; 26(9): 1732-1746, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28334913
11.
Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide-PNA Conjugates.
Bioconjug Chem
; 30(3): 793-799, 2019 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30645945
12.
SYT1-associated neurodevelopmental disorder: a case series.
Brain
; 141(9): 2576-2591, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30107533
13.
GAL3 receptor knockout mice exhibit an alcohol-preferring phenotype.
Addict Biol
; 24(5): 886-897, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29984872
14.
Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice.
Hum Mol Genet
; 25(18): 4080-4093, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27466204
15.
Inhibition of motor neuron death in vitro and in vivo by a p75 neurotrophin receptor intracellular domain fragment.
J Cell Sci
; 129(3): 517-30, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26503157
16.
Emerging therapies and challenges in spinal muscular atrophy.
Ann Neurol
; 81(3): 355-368, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-28026041
17.
Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies.
Cereb Cortex
; 27(7): 3630-3647, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27496536
18.
Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43.
Hum Mol Genet
; 24(6): 1655-69, 2015 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25410660
19.
Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms.
Proc Natl Acad Sci U S A
; 111(9): 3620-5, 2014 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-24550511
20.
Disease Mechanisms in ALS: Misfolded SOD1 Transferred Through Exosome-Dependent and Exosome-Independent Pathways.
Cell Mol Neurobiol
; 36(3): 377-81, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26908139