Detalhe da pesquisa
1.
Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators.
BMC Neurosci
; 15: 109, 2014 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25242351
2.
The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold.
BMC Neurosci
; 14: 90, 2013 Aug 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-23981345
3.
Evidence for a significant role of alpha 3-containing GABAA receptors in mediating the anxiolytic effects of benzodiazepines.
J Neurosci
; 25(46): 10682-8, 2005 Nov 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-16291941
4.
A pyridazine series of alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
J Med Chem
; 49(8): 2600-10, 2006 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-16610803
5.
Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.
J Med Chem
; 49(4): 1235-8, 2006 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-16480260
6.
Behavioral and qEEG effects of the PDE10A inhibitor THPP-1 in a novel rhesus model of antipsychotic activity.
Psychopharmacology (Berl)
; 233(13): 2441-50, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27117142
7.
Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys.
Sleep
; 39(3): 603-12, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26943466
8.
Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs.
Front Behav Neurosci
; 8: 182, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24904334
9.
Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition.
Sci Transl Med
; 5(179): 179ra44, 2013 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-23552372
10.
Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators.
Front Neurosci
; 7: 254, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-24399926
11.
Quantitative electroencephalography within sleep/wake states differentiates GABAA modulators eszopiclone and zolpidem from dual orexin receptor antagonists in rats.
Neuropsychopharmacology
; 38(12): 2401-8, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23722242
12.
Imidazo[1,2-b][1,2,4]triazines as alpha2/alpha3 subtype selective GABA A agonists for the treatment of anxiety.
Bioorg Med Chem Lett
; 16(6): 1477-80, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16386900
13.
TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.
J Pharmacol Exp Ther
; 316(1): 410-22, 2006 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-16183706