Detalhe da pesquisa
1.
Interrogating dense ligand chemical space with a forward-synthetic library.
Proc Natl Acad Sci U S A
; 116(23): 11496-11501, 2019 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31113876
2.
Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering.
Angew Chem Int Ed Engl
; 59(48): 21520-21524, 2020 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32816380
3.
A Versatile Strategy for the Synthesis of 4,5-Dihydroxy-2,3-Pentanedione (DPD) and Related Compounds as Potential Modulators of Bacterial Quorum Sensing.
Molecules
; 23(10)2018 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30301207
4.
An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB-Utilizing a Reversible Covalent Tethering Approach.
J Med Chem
; 64(12): 8423-8436, 2021 06 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34076416
5.
Clinical candidates modulating protein-protein interactions: The fragment-based experience.
Eur J Med Chem
; 167: 76-95, 2019 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30769242
6.
Set-up and screening of a fragment library targeting the 14-3-3 protein interface.
Medchemcomm
; 10(10): 1796-1802, 2019 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31814953
7.
The European Lead Factory: A Blueprint for Public-Private Partnerships in Early Drug Discovery.
Front Med (Lausanne)
; 3: 75, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-28154815
8.
Identification, design, synthesis, and pharmacological activity of (4-ethyl-piperazin-1-yl)-phenylmethanone derivatives with neuroprotective properties against beta-amyloid-induced toxicity.
Neuropharmacology
; 49(1): 86-96, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15992583
9.
Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective.
Drug Discov Today
; 20(11): 1310-6, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26429298
10.
Cesium Hydroxide: A Superior Base for the Catalytic Alkynylation of Aldehydes and Ketones and Catalytic Alkenylation of Nitriles.
Angew Chem Int Ed Engl
; 38(10): 1463-1465, 1999 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29711565